Th17与Treg在口腔黏膜病中的研究进展  

The Advances of Th17 and Treg in Oral Mucosal Disease

作　　者：鲁和震 梁文红[1] 

机构地区：[1]遵义医学院附属口腔医院,贵州遵义563000

出　　处：《中国医学创新》2015年第8期153-156,共4页Medical Innovation of China

基　　金：贵州省教育厅自然科学研究项目[黔教科(2009)0149号]

摘　　要：Th17细胞和Treg细胞是CD4+T淋巴细胞的新亚群,其发育和分化过程与Th1和Th2细胞是不同的,两者在功能上相互调节。Th17细胞主要介导机体的炎症反应及自身免疫性疾病的发生,而Treg细胞抑制免疫功能和维持免疫稳态有重要作用,两者存在相互转化的关系。目前研究发现Th17和Treg细胞与炎症反应性疾病,免疫性疾病和肿瘤等的发生发展相关,在口腔疾病中的作用也在逐步深入。本文就Th17细胞和Treg细胞的作用和调节及其与口腔黏膜病的研究进展做一综述。Th17 cells and Treg cells are new subsets of CD4＋ T-lymphocytes, who are different from Th1 and Th2 in the process of development and differentiation, and can also regulate each other in function. The Th17 cells mainly mediates the occurrence of the body＇s inflammatory response and autoimmune diseases, while the Treg cells play an important role in inhibition of immune function and maintenance of immune steady state. Also there is a relationship of mutual transformation between them. The current studys find that Th17 and Treg cells are involed in inflammatory diseases, autoimmune diseases and tumor development and also in oral diseases. This article makes a review on the function and regulation of Th17 cells and Treg cells and relations between them and oral mucosal diseases.

关 键 词：TH17细胞 TREG细胞 口腔黏膜疾病 

分 类 号：R781.5[医药卫生—口腔医学]