肠癌组织铁调素和膜转铁蛋白的表达及其与临床病理特征、贫血的关系  

Expressions of hepcidin and ferroportin in colorectal cancer and their associations with clinico-pathological features and anemia

作　　者：程旭[1] 陆晔[1] 李蓉[1] 严敏[1] 潘湘涛[1] 

机构地区：[1]苏州大学附属太仓医院血液肿瘤科,江苏苏州215400

出　　处：《中国临床研究》2015年第3期286-289,共4页Chinese Journal of Clinical Research

摘　　要：目的探讨肠癌患者与铁代谢相关的铁调素、膜转铁蛋白(FPN)的表达特点及其与临床特征、贫血的相关性。方法选取2009年1月至2014年1月在苏州大学附属太仓医院手术切除的62例肠癌患者的病理标本,另选择15例肠癌患者的癌旁正常肠粘膜组织作为对照组。应用SABC免疫组化方法检测62例肠癌患者癌组织中的铁调素及FPN的表达情况,并分析它们之间的相关性及其与临床病理特征、贫血的关系。结果 (1)铁调素在正常肠黏膜组织中阳性表达率为20.0%,肠癌组织中阳性表达率为66.1%,差异有统计学意义(P<0.01);FPN在正常肠黏膜组织中阳性表达率为86.7%,肠癌组织中阳性表达率为64.5%,差异无统计学意义(P>0.05)。(2)铁调素的表达与肿瘤T分期有关(P<0.05),而与年龄、性别、淋巴结转移、远处转移均无关(P均>0.05);FPN的表达与T分期及淋巴结转移有关(P<0.05,P<0.01),而与年龄、性别、远处转移均无关(P均>0.05)。(3)贫血与铁调素及FPN的表达无相关性(r=0.08,-0.04;P均>0.05);铁调素与FPN表达呈负相关(r=-0.39,P<0.01)。结论肠癌组织中铁调素的表达与患者肿瘤分期有关,并与FPN表达呈负相关,FPN表达与肿瘤分期及淋巴结转移有关。联合检测铁调素及FPN可作为反映肠道肿瘤生物学行为的客观指标。肠道肿瘤患者术前贫血与肿瘤组织中铁调素及FPN的表达无关。Objective To study the expression features of iron metabolism-related hepcidin and ferroportin （FPN） in pa- tients with colorectal cancer and their associations with clinical features and anemia. Methods The pathological specimens of 62 colorectal cancer patients that were surgically removed between January 2009 and January 2014 were collected, and matched normal intestinal mucosa tissues of para-carcinoma of 15 patients with colorectal cancer were selected as control. The expressions of hepeidin and FPN were detected by immunohistochemistry, and the correlation between them, their asso- ciations with clinico-pathological features and anemia were analyzed. Results The expression rate of hepcidin in eoloreetal cancer tissues increased compared with normal intestinal mucosa tissues （66.1% vs 20.0% ,P 〈 0.01 ）. There was no sig- nificant difference in FPN expression rate between colorectal cancer tissues and normal intestinal mucosa tissues （64.5% vs 86.7% ,P 〉0.05）. The expression rate of hepcidin was related to staging of tumor（ P 〈 0.05 ）, but were not related to age, gender,lymph node metastasis and distant metastasis （all P 〉 O. 05 ）. The expression of FPN was related to staging of tumor and lymph node metastasis （P 〈 0.05, P 〈 0.01 ）, but was not related to age, gender and distant metastasis （ all P 〉 0.05 ）. The anemia was not correlated with the expressions of hepcidin and FPN （ r = 0.08, - 0.04, all P 〉 0.05 ）. The hep- eidin expression was negatively correlated with FPN expression （ r = - 0.39, P 〈 0.01 ）. Conclusions The expression of hepcidin in colorectal cancer tissues is related to the staging of tumor, and negatively correlated with the FPN expression. The FPN expression is related to the staging of tumor and lymph node metastasis. The joint detection of hepcidin and FPN can serve as an objective index reflecting the biologic behavior of colorectal cancer. The preoperative anemia in gastrointes-tinal tumor patients is not related to the expression

关 键 词：铁调素 膜转铁蛋白 肠癌 贫血 TNM分期 淋巴结转移 远处转移 

分 类 号：R735.3[医药卫生—肿瘤]