脑转移瘤临床特点手术疗效及预后分析  

Analysis of clinical characteristics,surgical curative effect and prognosis for patients with brain metastasis

作　　者：王震[1] 王社军[1] 杜长生[1] 

机构地区：[1]武警总医院神经肿瘤外科,北京100039

出　　处：《中国实用神经疾病杂志》2015年第1期58-60,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨脑转移瘤的临床特点、手术疗效并分析预后。方法选择2006-01—2014-01本院诊治的60例脑转移瘤患者为研究对象。结果 60例患者中单发病灶45例(75.0%),多发15例(25.0%);原发病为肺癌35例(58.3%),乳腺癌8例(13.3%),其他恶性肿瘤17例(28.4%);病灶周围水肿、环形强化及毛刷样征象是常见的影像学特点;60例患者1a及2a生存率分别为58.3%和18.3%;单因素分析显示:肿瘤数目、治疗方式、病灶大小与患者生存期相关(P<0.05);Cox模型多因素分析结果显示:治疗方式及肿瘤数目是影响患者生存期的独立因素。结论脑转移瘤原发病以肺癌为最常见。治疗方式及肿瘤数目是生存期的影响因素,手术联合放化疗治疗效果最理想。Objective To investigate the clinical characteristics, surgical curative effect and prognosis for patients with brain metastasis. Methods Sixty patients with brain metastasis from January 2006 to January 2014 were selected as research subjects. Results There were 45 cases of single occurred tumor （75.0%） and 15 cases of multiple occurred tumor （25%） in 60 patients. The primary disease of 60 patients was 35 cases of lung cancer （58.3%） ,8 cases of cancer （13.3%） and 17 cases of other malignant tumors. The common imaging characteristics of 60 patients were perilesional edema, ring-enhancement and brush-like changes. The survival rates of 60 patients at 1 year and 2 years were 58.3% and 18.3% ,respectively. Single factor analysis results showed that the tumor number,therapeutic method and lesion size were correlated with the survival rate of patients （P;0.05）. Multivariate cox regression results showed that the tumor number and therapeutic methods were independence risk factors for survival rates. Conclusion Lung cancer is the most common primary disease for brain metastasis. The tumor number and therapeutic methods were independence risk factors for survival rates. Operation combined with chemo-ra- diotherapy has ideal effect on treating patients with brain metastasis.

关 键 词：脑转移瘤 临床特点 手术治疗 预后 

分 类 号：R739.41[医药卫生—肿瘤]