炎症营养指数与胃癌术后复发和预后的关系  

Relationship between the inflammatory-nutritional index and recurrence and prognosis in patients with gastric cancer

作　　者：张杨 陈佛来[2] 

机构地区：[1]北京市隆福医院普外科,100010 [2]首都医科大学附属北京同仁医院普外科,100010

出　　处：《实用医学杂志》2015年第6期936-939,共4页The Journal of Practical Medicine

摘　　要：目的：研究炎症营养指数（INI）与胃癌术后复发的关系,并探讨其对预后的影响。方法：纳入78例术后复发和64例术后无复发的胃癌患者,根据血清白蛋白和C反应蛋白比值计算INI,分析INI与病理特征的关系,采用受试者工作特征（ROC）曲线分析INI对术后复发的预测价值;运用Kaplan-Meier曲线和Cox回归模型分析INI与预后的关系。结果：复发组的INI较小,肿瘤直径较大,分化程度较低,浸润较深和TNM分期较高,差异均有统计学意义（均P〈0.01）;INI预测胃癌复发的敏感度为62.5%,特异度为79.5%,临界值为0.36,有统计学意义（P〈0.01）;低INI组的病理特征均差于高INI组,差异均有统计学意义（均P〈0.01）;INI预测胃癌预后的敏感度为65.9%,特异度为66.8%,临界值为0.34,有统计学意义（P〈0.01）;低INI组预后差于高INI组（48.8%vs 25.0%,P〈0.01）,INI是胃癌预后的独立危险因素（OR=1.78,95%CI：1.34~2.59,P〈0.01）。结论：INI与胃癌的病变特征紧密相关,是判断胃癌复发和预后的有效指标。Objective To investigate the correlation between the inflammatory-nutritional index（INI） and recurrence and prognosis in patients with gastric cancer. Methods A total of 78 cases patients of gastric cancer with recurrence and 64 cases without recurrence were enrolled. INI was calculated by the ratio of serum albumin and C-reactive protein. The value of INI predicting recurrence was analyzed using receiver operating characteristic curve（ROC）. According to this value, the Kaplan-Meier curves and Cox regression analysis were used to evaluate the effect of INI on prognosis. Results Compared with the control group, the recurrence group showed smaller INI, larger tumors, lower degree of differentiation, deeper invasion and higher TNM stage, the differences were statistically significant（all P〈0.01）; The INI significantly predicted the recurrence of gastric cancer, with a sensitivity of 62.5%, specificity of 79.5% and critical value of 0.36（P〈0.01）; Additionally, The pathological features were worse in the low INI group than the high INI group, the differences were statistically significant（P〈0.01）; The INI significantly predicted the prognosis of gastric cancer, with a sensitivity of 65.9%,specificity of 66.8% and the critical value of 0.34（P〈0.01）; Obviously, the survival rate was lower in the low INI group than the high INI group（48.8% vs 25.0%, P〈0.01）. Furthermore, INI was an independent risk factor for prognosis of gastric cancer（OR = 1.78, 95% CI： 1.34 - 2.59, P〈0.01）. Conclusion The INI is closely related to the characteristics of gastric cancer, it is an effective marker to predict recurrence and prognosis of gastric cancer.

关 键 词：胃肿瘤 炎症营养指数 复发 预后 

分 类 号：R735.2[医药卫生—肿瘤]