宫颈癌组织中HIF-1α的表达及临床意义的Meta分析  

Expression and clinical significance of HIF-1α in cervical cancer: a systematic review

作　　者：霍俊玲 王宇娟[1] 张晶[1] 吕娟[1] 李婧[1] 王赞宏[2] 

机构地区：[1]山西医科大学,太原030001 [2]山西医学科学院 山西大医院妇产科,太原030032

出　　处：《中华临床医师杂志（电子版）》2015年第6期69-72,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山西省科技攻关项目研究基金:自噬基因Beclin1联合HPV检测在宫颈癌中作用的推广研究(2014071011)

摘　　要：目的系统评价国内外有关缺氧诱导因子-1α（HIF-1α）表达水平与宫颈癌及其临床病理特征的关系。方法计算机检索The Cochrane Library（2014年第3期）、Pub Med、MEDLINE（Ovid）、EMbase、CNKI、CBM及Wan Fang Data,并手工检索相关杂志,查找国内外公开发表关于HIF-1α表达与宫颈癌及其临床病理特征相关性的病例-对照研究,检索时限均为从建库至2014年7月。按照纳入和排除标准筛选文献、提取资料并评价质量,然后采用Rev Man 5.2软件进行Meta分析。结果最终共纳入13个病例-对照研究,共计1 309例受试者,其中包括758例宫颈癌患者、323例宫颈上皮内瘤变患者和228例正常妇女。Meta分析结果显示：（1）HIF-1α在宫颈癌组与宫颈上皮内瘤变组[OR=4.49,95%CI（3.22,6.08）,P〈0.000 01]、宫颈癌组与正常宫颈组[OR=25.69,95%CI（15.42,42.80）,P〈0.000 01]表达差异均有统计学意义。（2）HIF-1α在淋巴结转移组与非淋巴结转移组[OR=6.72,95%CI（4.05,11.15）,P〈0.000 01]、临床分期Ⅰ-Ⅱ期与Ⅲ-Ⅳ期[OR=0.15,95%CI（0.08,0.29）,P〈0.000 1]的表达差异均有统计学意义。结论 目前国内外证据证明,HIF-1α的表达与宫颈癌及其临床病理特征有显著相关性。受纳入研究质量限制,上述结论尚需更多大样本、设计严谨的高质量研究加以验证。Objective To systematically review the correlation between the expression of HIF-1α and cervical cancer, as well as its clinically pathologic features. Methods Systematic and comprehensive literature was searched in The Cochrane Library（Issue 3, 2014）, Pub Med, MEDLINE（Ovid）, EMbase, CNKI, CBM and Wan Fang Data from inception to July 2014, to retrieve case-control studies published in the foreign and domestic areas on the correlation between the expression of HIF-1αand cervical cancer and its clinical pathologic features. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted the data, and evaluated the quality of the included studies. Then Meta-analysis was conducted using Rev Man 5.2 software. Results A total of 13 studies involved 1 309 women, 758 cervical cancer patients, 323 cervical intraepithelial neoplasis（CIN）,228 normal cervical. The results of Meta-analysis showed that, as for the positive rate of HIF-1α expression,significant differences were found between cervical cancer and CIN [OR=4.49, 95% CI（3.22, 6.08）,P〈0.000 01], cervical cancer and normal cervical tissues [OR=25.69, 95% CI（15.42, 42.80）, P〈0.000 01].Significant differences were found between cervical cancer with lymph node metastasis and that without lymph node metastasis [OR=6.72, 95% CI（4.05, 11.15）, P〈0.000 01], FIGO stagesⅠ-Ⅱ and FIGO stagesⅢ-Ⅳ（OR=0.15, 95% CI 0.08 to 0.29, P〈0.000 1）. Conclusion Current foreign and domestic evidence shows that, HIF-1α expression is significantly correlated to cervical cancer and its clinically pathologic features. Due to the quality limitation of the included studies, more large scale, well-designed and high quality studies are needed for further verifying the aforementioned conclusion.

关 键 词：缺氧诱导因子1 Α亚基 宫颈肿瘤 META分析 病例对照研究 

分 类 号：R737.33[医药卫生—肿瘤]