脑梗死患者血清抗心磷脂抗体和血管内皮生长因子水平与卒中后认知障碍的关系  

The relationship between the serum ACA, VEGF concentration and cognitive impairment in patients with cerebral infarction

作　　者：庄献博 徐光军[1] 王未飞[1] 单广振[1] 杨霞峰[1] 

机构地区：[1]聊城市人民医院神经内科,聊城252000

出　　处：《中华行为医学与脑科学杂志》2015年第2期152-154,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的 探讨脑梗死患者血清抗心磷脂抗体（ACA）、血管内皮生长因子（VEGF）水平与缺血性卒中患者认知障碍的关系.方法 收集2014年3-12月在本院神经内科住院治疗的急性脑梗死患者128例.根据蒙特利尔认知评估（MoCA）进行认知功能评分,128例脑梗死患者分为有认知功能障碍（A组,53例）和无认知功能障碍（B组,75例）,两组采用ELISA法测定血清ACA、VEGF浓度并比较两组血清ACA、VEGF浓度的差异,分析血清ACA、VEGF浓度与缺血性卒中后认知障碍的关系.结果 认知功能障碍组血清ACA浓度[（0.86±0.16） mg/L]明显高于认知功能正常组[（0.52±0.08） mg/L] （P＜0.01）;认知功能障碍组血清VEGF浓度[（197.60±7.48） pg/ml]显著低于认知功能正常组[（205.80±8.52） pg/ml] （P＜0.05）;多因素Logistic回归分析显示,ACA、VEGF是缺血性脑卒中后认知功能障碍的独立影响因素（ACA：B=2.841,OR=0.33,95％ CI =0.118-0.926,P=0.025;VEGF：B=-1.674,OR=4.99,95％ CI=1.688-4.741,P=0.034）.结论 ACA、VEGF在缺血性脑卒中后认知障碍的发生及发展过程中可能起重要作用.Objective To explore the relationship between the serum anticardiolipin antibody （ACA）,vascular endothelial grow factor （VEGF） concentration and cognitive impairment in patients with ischemic stroke.Methods Totally 128 cases with acute ischemic stroke were admmitted in stroke unit ward of our hospital during June 2014 to December 2014.According to the score of Montreal cognitive assessnent （MoCA）,128 patients with ischemic stroke were divided into groups A （53 cases with cognitive impairment） and group B （75 cases without cognitive impairment）.The concentrations of serum ACA,VEGF were quantitatively determinated by ELISA.The differences of serum ACA,VEGF concentrations were compared between the two groups.Results Compared with normal cognitive function group,the cognitive impairment patients had significantly higher ACA concentration （（0.86±0.16） mg/L vs （0.52±0.08） mg/L,P〈0.01）,and lower VEGF concentration （（197.60±7.48） pg/ml vs （205.80±8.52） pg/ml,P〈0.05）.Logistic regression revealed that ACA and VEGF were independent effect factors for cognitive impairment （ACA：B =2.841,OR =0.33,95 % CI =0.118-0.926,P=0.025.V EGF：B =-1.674,OR =4.99,95% CI =1.688-4.741,P=0.034）.Conclusion ACA and VEGF may play an important role in cognitive impairment after ischemic stroke.

关 键 词：缺血性卒中 认知功能障碍 抗心磷脂抗体 血管内皮生长因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]