DNA甲基化与情感障碍  

DNA methylation and affective disorder

作　　者：崔洪雨[1] 王振华[1] 王承敏[1] 施梅[1] 

机构地区：[1]哈尔滨医科大学附属第一医院精神卫生中心,哈尔滨150001

出　　处：《中华行为医学与脑科学杂志》2015年第2期189-192,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：黑龙江省自然科学基金项目（D2004-54）;黑龙江省博士后科研启动金资助项目（LBH-Q12031）

摘　　要：目的 DNA甲基化成为近年来表观遗传学的研究热点.越来越多的研究表明DNA甲基化在情感障碍的发病中也扮演着重要角色.本文综述了DNA甲基化的分子机制,介绍了DNA甲基化与情感障碍的关系,并在此基础上对重性抑郁症与双相情感障碍相关基因DNA甲基化的最新研究进展进行了综述.方法 检索2013年6月至2015年1月PUBMED数据库,外文医学信息资源检索平台,CNKI,万方数据库等数据库的相关文章.检索式TI：[depression OR bipolar disorder OR affective disorder] AND All field：DNA methylation.摘要阅读,缩小文献范围.了解实验设计思路,如：样本为血细胞或脑实质中的DNA,甲基化检测方法,检测基因以及甲基化位点等.所得文献英文168篇,中文32篇.阅读全文,保留近5年有关重性抑郁症及双相障碍相关基因的DNA甲基化文献.结果 最终确定29篇文章其中2篇中文文章.大部分是与疾病相关受体基因的表观遗传学研究.结论 重性抑郁症和双相障碍与GR、BDNF、5-HTR、SLC6A4等多个基因启动子区DNA甲基化水平升高及COMT基因启动子区甲基化水平降低有关.本文仅从情感障碍的角度综述了DNA甲基化与疾病的关系,对其他精神疾病的表观遗传研究涉及较少,有待今后完善.Objective Recent years,epigenetics research mainly focused on DNA methylation.A growing body of research indicated that DNA methylation may play vital role in etiology of affective disorder.With brief introduction of DNA methylation molecular mechanisms and relevance of DNA methylation to affective disorder,this review focuses on some supporting evidence which are recently emerged in major depressive disorder （MDD） and bipolar disorder related gene DNA methylation.Methods We retrievaled related articles from databases,such as PUBMED,Foreign medical information resources retrieval platform,CNKI,Wanfang database,ect,from 2013-06 to 2015-01.Index strategy TI：[depression OR bipolar disorder OR affective disorder] AND All field：DNA methylation.Reading and narrowing the scope of the articles,the experimental design was understanded,such as DNA from either blood cell or brain parenchyma of sample,methods of methylation detection,gene detected and methylation position,etc.The articles included 168 in English and 32 in Chinese.The whole and retained the articles were red about MDD and bipolar disorder related gene DNA methylation in recent five years.Results Eventually,the article includes 29 articles and two of in Chinese.Most of them are receptor gene epigenetics research associated with disease.Conclusion MDD and bipolar disorder are associated with the higher of DNA methylation levels in multiple gene promoter region,such as GR,BDNF,5-HTR,SLC6A4 and the lower of COMT.This article only from the perspective of affective disorder reviewed the relationship between DNA methylation and diseases.None of other diseases epigenetics research,there is to be perfected in future.

关 键 词：DNA甲基化 情感障碍 表观遗传 

分 类 号：R749.4[医药卫生—神经病学与精神病学]