流式细胞术检测多发性骨髓瘤免疫表型和残留病灶的研究进展  

Research Progress on Multiple Myeloma Immunophenotyping and Minimal Residual Disease Detected by Flow Cytometry——Review

作　　者：李翰卿[1] 翟勇平[1] 

机构地区：[1]南京军区南京总医院血液病科,江苏南京210002

出　　处：《中国实验血液学杂志》2015年第1期241-245,共5页Journal of Experimental Hematology

基　　金：南京军区南京总医院院管课题(2014017)

摘　　要：多发性骨髓瘤(multiple myeloma,MM)是恶性浆细胞在骨髓中克隆性增生的疾病,目前仍是一种难以治愈的血液肿瘤。流式细胞术已广泛用于MM患者的免疫表型以及微小残留病灶监测,辅助MM诊断、病情监测和预后判断。根据浆细胞表面抗原表达不同可区分正常浆细胞和恶性浆细胞,目前许多免疫标注的临床意义已阐明,但对一些表型的临床意义仍有争议,检测方案和设门方法也未统一。本文对近年来多发性骨髓瘤免疫表型和残留病灶流式检测的研究进展作一综述。Multiple myeloma （MM） is a haematological malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow and remained incurable. Flow cytometry has been widely used in the detection of immunophenotype and minimal residual disease, diagnosis, monitoring and prognosis of MM. Normal plasma cells and malignant plasma cells can be distinguished according to different cell surface antigen expression. The clinical significane of many immune markes has been elucidated. However, the clinical significance of some phenotype remains controversial, the detection scheme and gating strategy are not unified. This review discusses the recent research progress on detection of MM immunophenotype and minimal residual disease by flow cytovetrv.

关 键 词：多发性骨髓瘤 免疫分型 微小残留病灶 流式细胞术 

分 类 号：R733.3[医药卫生—肿瘤] R446.1[医药卫生—临床医学]