艾滋病猕猴模型的肠道病理学研究进展  

The advances of intestinal pathological changes in AIDS macaque model

作　　者：张琳萄 夏雪山[1] 郑永唐[2] 

机构地区：[1]昆明理工大学生命科学与技术学院,650500 [2]中国科学院昆明动物研究所 中国科学院和云南省动物模型与人类疾病机理重点实验室,650223

出　　处：《免疫学杂志》2015年第3期265-269,276,共6页Immunological Journal

基　　金：国家自然科学基金(81172876,81273251,81471620,U1202228);国家重大科学研究计划课题(2012CBA01305);国家科技重大专项课题(2012ZX10001-007,2013ZX10001-002)

摘　　要：HIV是导致AIDS的病原体,HIV感染后会引起机体免疫缺陷并导致多个器官的损伤,其中肠道损伤是HIV感染后最常见的病变之一。肠道损伤既是HIV致病的直接诱因,也能间接地影响机体多项免疫功能进而加速疾病进展。非人灵长类动物在组织结构、免疫、生理和代谢等方面与人类具有高度相似性,而且在SIV感染后的发病过程和病理特征与人AIDS症状非常相似,故其作为HIV研究的模型动物被广泛运用。本文对SIV感染非人灵长类所致的肠道组织病理变化,免疫细胞及分子的变化,肠道菌群及易位对AIDS的影响,以及治疗对肠道损伤的作用等方面研究进展进行介绍。通过对SIV感染后组织病理学和免疫学变化的认识,将有助于了解艾滋病发病机制,研发抗HIV药物和疫苗以及研究病人的治疗策略。HIV is the pathogen of AIDS and can cause immunodeficiency and damage to organs.Gastrointestinal（GI） injury has been commonly seen in patients with HIV infection, which is the major pathogenic mechanism of AIDS, and also induces immune dysfunction and accelerates disease progression. Non-human primates show highly similarity with human beings in organizational structure, immunity, physiology and metabolism. The disease process and pathological characteristic in SIV infected nonhuman primate models shown closely resemble HIV infection and AIDS, so they have been widely used as the animal model for studying HIV infection. In this review, we summarize the histopathologic changes of GI tract, the variations of immune cells and molecules, effects of gut microbiomes and translocation on AIDS, the role of therapy on GI injury. Studying the histopathologic and immunologic changes of SIV infection will help to study the disease mechanism, develop antiHIV drugs and vaccine, and also benefit the treatment of HIV infection.

关 键 词：AIDS SIV 灵长类动物 胃肠道 病理学变化 

分 类 号：R-332[医药卫生] R512.91