急性髓系白血病相关基因的DNA甲基化  

Progress in DNA Methylation Research on Genes Associated with Acute Myeloid Leukemia

作　　者：洪青晓 叶华丹[1] 汤琳琳[1] 蒋丹捷 季慧慧[1] 戴东君 欧阳桂芳[2] 段世伟[1] 

机构地区：[1]宁波大学医学院,浙江省病理生理学技术研究重点实验室,宁波315211 [2]宁波市第一医院血液科,宁波315010

出　　处：《中国细胞生物学学报》2015年第2期299-308,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31100919;81371469);浙江省自然科学基金(批准号:LR13H020003);宁波市自然科学基金(批准号:2007A610077;200701A6304004);宁波大学王宽诚幸福基金;宁波市社会发展科研项目(批准号:2010C50019)资助的课题~~

摘　　要：急性髓系白血病(acute myeloid leukemia,AML)是异质性造血干细胞恶性克隆性疾病,主要表现为外周血、骨髓以及其他组织中的原始细胞克隆性扩增。近年来,AML发病率呈逐年增加的趋势,对人类健康产生巨大的威胁。在不同种族及不同性别中,AML发病率及死亡率存在显著差异。AML是一种复杂疾病,与遗传突变及异常表观遗传修饰密切相关。DNA甲基化是重要的表观遗传修饰,AML相关基因的异常DNA甲基化修饰对疾病的发生发展极其重要。该文对AML相关基因的异常甲基化修饰进行了系统的作用机制分析,并对重要基因进行了功能分类。该文总结的具有异常DNA甲基化修饰的基因,有望辅助预测AML的治疗及预后效果,并为设计个体化AML治疗方案提供全新的思路。Acute myeloid leukemia（AML） is a heterogeneous hematologic malignancy, characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow and other tissues. The incidence of AML increased rapidly in recent years, which has become a huge threat to human health. The incidence and mortality rates of AML are significantly different in various ethnic populations and different genders. As a complex disease, AML is contributed by both genetic mutations and aberrant epigenetic modification. DNA methylation is one kind of important epigenetic modifications. The aberrantly methylated AML-related genes are pivotal to the risk and development of AML. This review collected the aberrantly methylated genes in AML and outlined the mechanisms by which contributed to the risk and pathogenesis of AML. A further classification of these genes was also provided according to their biological functions. These genes might help predict the outcomes of treatment and prognosis of AML, and help develop new individualized chemotherapeutic procedures for AML.

关 键 词：急性髓系白血病 表观遗传学 甲基化 

分 类 号：R733.71[医药卫生—肿瘤]