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机构地区:[1]泸州医学院附属医院病理科,四川省泸州市646000 [2]泸州医学院附属医院肿瘤科,四川省泸州市646000
出 处:《世界华人消化杂志》2015年第4期613-617,共5页World Chinese Journal of Digestology
摘 要:目的:探讨食管鳞癌中肿瘤出芽与D2-40标记淋巴管浸润(lymphatic vessel invasion,LVI)及淋巴结转移的相关关系.方法:参照Ueno标准,通过HE染色观察并判断70例食管鳞癌肿瘤出芽情况,采用免疫组织化学(SP法)技术检测D2-40表达并观察肿瘤细胞浸润淋巴管情况,分析肿瘤出芽、LVI与临床病理指标间的关系.结果:70例食管鳞癌的高级别肿瘤出芽率和LVI阳性率分别为30%和40%,二者均与淋巴结转移、临床分期呈正相关(P<0.01).LVI与肿瘤分化程度呈负相关(P<0.05).肿瘤出芽与LVI符合率为72.86%.结论:联合检测肿瘤出芽和LVI可作为食管鳞癌判断淋巴结转移的预测因子.AIM: To investigate the relationship among tumor budding, D2-40 monoclonal antibodyl abeled lymphatic vessel invasion( LVI) and lymph node metastasis in esophageal squamous cell carcinoma(ESCC). METHODS: According to the Ueno criteria, we assessed tumor budding by HE staining and examined the expression of D2-40 and LVI by immunohistochemistry in 70 ESCC cases. RESULTS: The positive rates of high-grade tumor budding and LVI were 30% and 40%, respectively. Both tumor budding and LVI was positively correlated with lymph node metastasis and clinical stage(P 〈 0.01). LVI was negatively correlated with tumor differentiation(P 〈 0.05). The coincidence rate between tumor budding and LVI was 72.86%. CONCLUSION: The joint detection of tumor budding and LVI will be useful for forecasting lymph node metastasis in ESCC.
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