Cajal间质细胞与胆道系统疾病的研究进展  

Interstitial cells of Cajal and biliary system diseases

作　　者：黄振鹏[1] 杨艳[1] 杨斌[1] 余保平[1] 

机构地区：[1]武汉大学人民医院消化科,湖北省武汉市430060

出　　处：《世界华人消化杂志》2015年第3期404-408,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81170351~~

摘　　要：Cajal间质细胞(interstitial cells of Cajal,ICCs)是西班牙神经解剖学家Santiago Rarnon Cajal于1893年首次观察到其形态结构并对其描述,ICCs主要存在食管、胃、十二指肠、空肠、回肠、盲肠、结肠、直肠、阑尾等消化管中,有胃肠道平滑肌动力起搏、消化系慢电波传播、介导和调节胃肠道神经递质等作用.近年来,在胆道系统中也发现并证实有I C C s存在,胆道系统I C C s有产生和传播胆囊自发性节律、调节胆囊运动、引起胆囊收缩等功能,并在胆道系统疾病,如胆石症、胆囊恶性间质瘤等发病中可能存在重要作用,本文就胆道系统ICCs分布、形态学和超微结构、ICCs与胆道系统生理和病理研究进展做一综述.Interstitial cells of Cajal（ICCs） were first identified using histological staining techniques and best described in the gastrointestinal tract by Santiago Rarnon Cajal, who was a Spanish neuroanatomist, in 1893. Over the past about 100 years, studies have demonstrated that ICCs mainly exist in the esophagus, stomach, proximal duodenum wall, small and large bowel, ileum, appendix, colon and so on. They generate electrical pacemaker activity in gastrointestinal smooth muscles, propagating digestive tract slow wave, mediating and regulating gastrointestinal tract neurotransmitters. In recent years, ICCs have also been found and confirmed to be present in the biliary system, including the gallbladder and extrahepatic biliary duct, the cystic duct and the common bile duct, both in the guinea pigs and humans. Recent studies have confirmed that ICCs in the biliary system are closely related with producing and spreading the gallbladder spontaneous rhythm, adjusting the gallbladder contraction and gallbladder movement. Besides, ICCs play an important role in a variety of diseases of the biliary system, such as cholelithiasis and biliary system malignant tumors. This paper reviews ICCs in the biliary system in terms of their distribution, morphology, ultrastructure, and role in pathophysiology of biliary system diseases.

关 键 词：CAJAL间质细胞 胆道 形态学 生理学 病理生理学 

分 类 号：R575.7[医药卫生—消化系统]