中药联合DA化疗方案治疗老年急性髓系白血病的疗效  

Efficacy of combined use of Chinese medicine with DA chemotherapy regimen in treating senile patients with acute myelogenous leukemia

作　　者：刘珂[1] 

机构地区：[1]河南科技大学第一附属医院血液病科,471003

出　　处：《江苏医药》2015年第4期410-412,共3页Jiangsu Medical Journal

摘　　要：目的观察中药联合DA化疗方案治疗老年急性髓系白血病患者的疗效及安全性。方法老年急性髓系白血病患者86例分为两组:C组40例,予常规DA化疗方案(阿糖胞苷+柔红霉素)静脉滴注治疗;A组46例,加用益气健脾补肾汤内服治疗。比较化疗2个疗程的临床疗效、骨髓抑制及不良反应发生情况。结果 A、C组临床总有效率相仿(87.0%vs.82.5%)(P>0.05)。A组治疗1、7、14d时的Hb、WBC和Plt均低于C组(P<0.05)。A组不良反应发生率低于C组(P<0.05)。结论中药联合DA化疗方案治疗老年急性髓系白血病疗效较单用DA化疗方案好,不良反应少。Objective To observe the efficacy and safety of combined use of Chinese medicine with DA chemotherapy regimen in treating senile patients with acute myelogenous leukemia（AML）.Methods Eighty-six senile patients with AML were divided into two groups.Conventional DA（cytarabine＋daunorubicin）chemotherapy regimen was performed in group C（40cases）and additional Yiqi Jianpi Bushen decoction was orally taken in group A（46cases）.Clinical efficacy,myelosuppression and adverse effects after two cycles of chemotherapy were compared between two groups.Results Overall effectiveness rates of two groups were similar（87.0% vs.82.5%）（P〉0.05）.Hb,WBC and Plt on the 1^st,7^th and 14^ th day during treatment were lower in group A than those in group C（P〈0.05）.Adverse effect rate was lower in group A than that in group C（P〈0.05）.Conclusion Chinese medicine combined with DA chemotherapy regimen has better efficacy and less adverse effects than DA chemotherapy regimen alone in treating senile patients with AML.

关 键 词：急性髓系白血病 DA化疗方案 老年 

分 类 号：R733[医药卫生—肿瘤]