Region 2 of 8q24 is associated with the risk of aggressive prostate cancer in Caribbean men of African descent from Guadeloupe （French West Indies）  

8q24ll区与瓜德罗普岛（法属西印度群岛）的非洲裔加勒比男性前列腺癌进展的风险相关

作　　者：Geraldine Cancel-Tassin Marc Romana Cecile Gaffory Pascal Blanchet Olivier Cussenot Luc Multigner 

机构地区：[1]CeRePP, Pitie-Salpetriere Hospital, Paris 75013, France [2]ER2, UPMC Univ Paris 6, Paris 75020, France [3]3U665, Inserm, Pointe a Pitre 97159, Guadeloupe, French West Indies [4]Department of Urology, Assistance Publique Hopitaux de Paris, Tenon Hospital, GHU Est, Paris 75020, France [5]U1085 - IRSET, Inserm, Pointe Pitre 97154, Guadeloupe, French West Indies [6]Department of Urology, CHU Pointe--Pitre/Abymes, Pointe Pitre 97159, Guadeloupe, French West Indies.

出　　处：《Asian Journal of Andrology》2015年第1期117-119,I0010,共4页亚洲男性学杂志（英文版）

摘　　要：Multiple regions of the genome have been associated with the risk of prostate cancer in Caucasians, particularly including several polymorphisms located at 8q24. Region 2 of 8q24 has been repeatedly found to be associated with the risk of prostate cancer among men of African descent, although one study performed in the Caribbean island of Jamaica did not report this finding. In this study, the single nucleotide polymorphism rs16901979, located in region 2 of 8q24, was genotyped in 498 cases of histologically confirmed prostate cancer and 541 controls from the French Caribbean islands of Guadeloupe, where the population is largely of African descent. The AA genotype and the A allele at rs16901979 were associated with elevated risks of prostate cancer （odds ratios [ORs] = 1.84, 95% confidence interval [95% CI] = 1.26-2.69, P= 0.002 and OR = 1.36, 95% CI = 1.13-1.64, P= 0.001, respectively）. Following stratification of the patients by disease aggressiveness, as defined by the Gleason score, the pooled genotypes AC ＋ AA were associated with a higher risk of a Gleasen score 〉7 at diagnosis （OR = 1.79, 95% CI = 1.17-2.73, P= 0.007）. In summary, the A allele at rs16901979 was associated with the risk of prostate cancer in the Caribbean population of Guadeloupe, confirming its involvement in populations of African descent. Moreover, our study provides the first evidence of an association between this variant and the risk of aggressive prostate cancer.Multiple regions of the genome have been associated with the risk of prostate cancer in Caucasians, particularly including several polymorphisms located at 8q24. Region 2 of 8q24 has been repeatedly found to be associated with the risk of prostate cancer among men of African descent, although one study performed in the Caribbean island of Jamaica did not report this finding. In this study, the single nucleotide polymorphism rs16901979, located in region 2 of 8q24, was genotyped in 498 cases of histologically confirmed prostate cancer and 541 controls from the French Caribbean islands of Guadeloupe, where the population is largely of African descent. The AA genotype and the A allele at rs16901979 were associated with elevated risks of prostate cancer （odds ratios [ORs] = 1.84, 95% confidence interval [95% CI] = 1.26-2.69, P= 0.002 and OR = 1.36, 95% CI = 1.13-1.64, P= 0.001, respectively）. Following stratification of the patients by disease aggressiveness, as defined by the Gleason score, the pooled genotypes AC ＋ AA were associated with a higher risk of a Gleasen score 〉7 at diagnosis （OR = 1.79, 95% CI = 1.17-2.73, P= 0.007）. In summary, the A allele at rs16901979 was associated with the risk of prostate cancer in the Caribbean population of Guadeloupe, confirming its involvement in populations of African descent. Moreover, our study provides the first evidence of an association between this variant and the risk of aggressive prostate cancer.

关 键 词：African Continental Ancestry Group AGGRESSIVENESS Caribbean region genetic predisposition to disease prostaticneoplasms 

分 类 号：R[医药卫生]