Vlale patients with terminal renal failure exhibit low serum levels of antimullerian hormone  

终末期肾衰竭男性患者血清中抗苗勒管激素水平降低

作　　者：Dag Eckersten Aleksander Giwercman Anders Christensson 

机构地区：[1]Department of Nephrology and Transplantation [2]Reproductive Medicine Centre, Lund University, Skane University Hospital, Malmo, Sweden.

出　　处：《Asian Journal of Andrology》2015年第1期149-153,I0012,共6页亚洲男性学杂志（英文版）

摘　　要：Male reproductive function is impaired during end-stage renal disease （ESRD）. Disturbance of the hypothalamic-pituitary-gonadal axis, and therefore the regulation of sex hormones, is one of the major causes. Our focus was to include antimLillerian hormone （AMH） and inhibin B concentrations. Twenty male patients on hemodialysis, median age 40 （26-48） years, were analyzed for follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, prolactin, sex hormone-binding globulin （SHBG）, testosterone, estradiol, AMH and inhibin B levels. We used 144 proven fertile men, median age 32 （19-44） years as a control group and analyzed differences using multiple linear regression. Males with ESRD demonstrated higher mean values for prolactin, 742 versus normal 210 mlE 1-1 （95% confidence interval （Cl）： 60.3, 729）, LH, 8.87 versus normal 4.5 IE 1-1 （95% Ch 2.75, 6.14）, and estradiol 89.7 versus normal 79.0 pmol 1-1 （95% CI： -1.31, -0.15）. Mean value for AMH was lower, 19.5 versus normal 47.3 pmol 1-1 （95% Cl. -37.6, -11.6）. There were no differences found for FSH, SHBG, inhibin B and testosterone. The most important difference was found for AMH, a marker of Sertoli cell function in the testes, which decreased by close to 60% when compared with controls. Combined with an increase in LH, these findings may indicate a dysfunction of Sertoli cells and an effect on Leydig cells contributing to a potential mechanism of reproductive dysfunction in men with ESRD.Male reproductive function is impaired during end-stage renal disease （ESRD）. Disturbance of the hypothalamic-pituitary-gonadal axis, and therefore the regulation of sex hormones, is one of the major causes. Our focus was to include antimLillerian hormone （AMH） and inhibin B concentrations. Twenty male patients on hemodialysis, median age 40 （26-48） years, were analyzed for follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, prolactin, sex hormone-binding globulin （SHBG）, testosterone, estradiol, AMH and inhibin B levels. We used 144 proven fertile men, median age 32 （19-44） years as a control group and analyzed differences using multiple linear regression. Males with ESRD demonstrated higher mean values for prolactin, 742 versus normal 210 mlE 1-1 （95% confidence interval （Cl）： 60.3, 729）, LH, 8.87 versus normal 4.5 IE 1-1 （95% Ch 2.75, 6.14）, and estradiol 89.7 versus normal 79.0 pmol 1-1 （95% CI： -1.31, -0.15）. Mean value for AMH was lower, 19.5 versus normal 47.3 pmol 1-1 （95% Cl. -37.6, -11.6）. There were no differences found for FSH, SHBG, inhibin B and testosterone. The most important difference was found for AMH, a marker of Sertoli cell function in the testes, which decreased by close to 60% when compared with controls. Combined with an increase in LH, these findings may indicate a dysfunction of Sertoli cells and an effect on Leydig cells contributing to a potential mechanism of reproductive dysfunction in men with ESRD.

关 键 词：antimOIlerian hormone chronic kidney disease end-stage renal disease INFERTILITY inhibin B sex hormones 

分 类 号：R[医药卫生]