HuLDO:人类肝脏疾病本体的构建及应用  

Construction and application of Human Liver Disease Ontology

作　　者：杨春媛[1,2] 李满生[2] 朱云平[2] 

机构地区：[1]北京协和医学院,中国医学科学院基础医学研究所,北京100730 [2]军事医学科学院放射与辐射医学研究所蛋白质组学国家重点实验室,北京蛋白质组研究中心,北京102206

出　　处：《军事医学》2015年第2期111-116,共6页Military Medical Sciences

基　　金：国家973计划资助项目(2011CB910600;2013CB911200);国家863计划资助项目(2012AA020409;2012AA020201);国家自然科学基金资助项目(201105121;21275160)

摘　　要：目的中国是多种常见肝病的高发国家,肝脏疾病的研究对提高防治水平,保障人民健康有着重要的意义。为了全面收集、整理、共享和分析分散于现有数据库和文献资料中的肝脏生理病理学知识,该研究构建了人类肝脏疾病本体HuL DO并展开多方面应用。方法 HuL DO是参考疾病相关的多个权威术语集和肝脏病学专著而构建的,依据该本体中的疾病名称列表,从现有数据库中收集各种肝病的相关数据,以本体结构为数据组织框架构建肝病知识库,以本体为字典挖掘肝病与基因的关系。结果 HuL DO是目前最全面的肝病概念分类系统,以该本体为基础建立了一整套肝病知识的收集、挖掘和展示的工具和策略。结论 HuL DO是全面收集、高效分享和灵活分析各类肝病数据和知识的重要工具。肝病本体的下载地址是ftp://liveratlas.hupo.org.cn/5.liver%20Disease%20Ontology/。Objective China has the biggest population of commonly encountered liver diseases,so hepatology researches are of great importance to human health. In order to comprehensively collect / organize and effectively share / display liver physiopathology knowledge scattered around databases and literature,a Human Liver Disease Ontology（ HuL DO） is built and applied in many ways. Methods HuL DO systematically classified and annotated various human liver diseases based on extensive cross mapping and integration of several authoritative nomenclatures of diseases and two monographs of hepatology. Results In the present version,HuL DO encompassed knowledge of 227 human liver diseases and was enriched by plenty of synonyms,definitions,descriptions,references,and logical or pathological relations between different diseases. Compared with other existing nomenclatures,HuL DO extended far beyond them in the scope of liver diseases. Several applications of HuL DO in database construction,knowledge collection and text mining were also described. Conclusion HuL DO offers a sound basis for knowledge mining,data integration and data analysis in the field of hepatology. HuL DO is publicly available at ftp： / / liveratlas. hupo. org. cn /5. liver 5. liver% 20Disease% 20 Ontology /.

关 键 词：生物医学本体 肝脏疾病 数据库构建 文本挖掘 生物信息学 

分 类 号：R575[医药卫生—消化系统]