Ki-67、Her-2在乳腺浸润性导管癌中的表达与临床特征相关性研究  

Correlation between expression of Ki-67 and Her-2 and clinical features in breast invasive ductal carcinoma

作　　者：栗辰[1] 进淑娟[1] 刘晓静[1] 韩小伟[1] 郝晓鹏[1] 庞汉民[1] 黄焰[1] 

机构地区：[1]军事医学科学院附属医院乳腺外科,北京100071

出　　处：《军事医学》2015年第2期140-142,146,共4页Military Medical Sciences

摘　　要：目的探讨Ki-67、Her-2在乳腺浸润性导管癌中的表达情况及二者与临床特征的相关性。方法收集2012年1月至2014年9月军事医学科学院附属医院202例乳腺浸润性导管癌患者的临床及病理学资料,统计分析Ki-67、Her-2的表达与临床特征的相关性。结果在202例患者中,Ki-67阳性率为73.3%(148/202),Her-2阳性率为19.3%(39/202)。Ki-67的表达水平与组织学分级、激素受体(ER、PR)表达情况相关(P<0.05),与年龄大小、肿瘤直径、淋巴结转移均无关(P>0.05)。Her-2的表达与雌激素及孕激素受体表达相关(P<0.05),而与年龄大小、肿瘤直径、组织学分级、淋巴结转移均无关(P>0.05)。Ki-67低表达、Her-2表达阴性时与雌激素及孕激素受体阳性表达呈正相关(P<0.05),与年龄大小、肿瘤直径、组织学分级、淋巴结转移均无关(P>0.05)。Ki-67表达水平与Her-2表达之间无相关性(P<0.05)。结论 Ki-67高表达提示肿瘤组织学分级更高,分化程度更低,即肿瘤的恶性程度越高,越易转移;Ki-67高表达、Her-2阳性提示对内分泌治疗的敏感性低,治疗效果差;检测Ki-67、Her-2在乳腺浸润性导管癌中的表达对了解乳腺浸润性导管癌的恶性程度,指导患者个体化治疗及评估预后具有一定指导意义。Objective To analyze the correlation between the expression of Ki-67 and Her-2 and clinical features in breast invasive ductal carcinoma. Methods Clinical and pathological data of 202 female breast invasive ductal carcinoma patients were collected between January 2012 and September 2014. The correlation between the expression of Ki-67 and Her-2 and clinical features was analyzed. Results The positive rate of Ki-67 was 73. 3%（ 148 /202） and that of Her-2 was19. 3（ 39 /202）. The expression of Ki-67 was related to histological grading,ER and PR status（ P〉0. 05）,but not to age,tumor size or lymph node status（ P〉0. 05）. The expression of Her-2 was related to ER and PR status（ P〉0. 05）,but not to age,tumor size,histological grading,or lymph node status（ P〉0. 05）. Moreover,the low expression Ki-67 and negative expression of Her-2 were positvely corelated with the positive expression of hormone receptor [estrogen receptor（ ER）,progestin receptor（ PR） ]（ P〉0. 05）. Conclusion High expression of Ki-67 suggested that the differential grade of tumor was lower,malignant grade was higher,infiltration was stronger and metastasis was easier. High expression of Ki-67 and positive Her-2 suggests lower sensitivity to endocrine therapy and treatment. Detection of Ki-67 and Her-2 expression in breast invasive ductal carcinoma is of guiding significance for understanding the degree of malignancy and for evaluating prognosis.

关 键 词：KI-67 HER-2 乳腺肿瘤 临床特征 

分 类 号：R737.9[医药卫生—肿瘤]