0.375%罗哌卡因与0.25%布比卡因胸段硬膜外阻滞用于乳腺癌改良根治术的效果及安全性  

Effect and safety of thoracic epidural blocking of 0.375% ropivacaine and 0.25% bupivacaine for modified radical mastectomy

作　　者：徐翔[1] 李义贤[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院麻醉科,广东汕头515041

出　　处：《中国当代医药》2015年第8期120-121,128,共3页China Modern Medicine

摘　　要：目的比较0.375%罗哌卡因与0.25%布比卡因胸段硬膜外阻滞用于乳腺癌改良根治术的效果。方法选取本院64例乳腺癌患者,将其随机均分为对照组(0.25%布比卡因连续硬膜外阻滞)和观察组(0.375%罗哌卡因连续硬膜外阻滞),比较两组的疼痛评分、感觉阻滞起效时间、最高阻滞平面时间、阻滞范围及麻醉不良反应情况。结果两组手术各阶段的VAS评分、感觉阻滞起效时间及阻滞范围差异无统计学意义(P>0.05);观察组的最高阻滞平面时间短于对照组(P<0.05),不良反应发生率显著低于对照组(P<0.05)。结论 0.375%罗哌卡因与0.25%布比卡因均能安全用于乳腺癌改良根治术的麻醉,罗哌卡因诱导时间更短,安全范围更宽。Objective To compare the effect of thoracic epidural blocking of 0.375% ropivacaine and 0.25% bupiva- caine for modified radical mastectomy. Methods 64 cases with breast cancer in our hospital were randomly divided into the control group （treated with 0.25% bupivacaine continuous epidural anesthesia） and observation group （treated with 0.375% ropivacaine continuous epidural anesthesia）.Pain score,onset time of sensory block,the maximum plane blocking time,block range and adverse reaction of anesthesia in the two groups were compared, Results There was no statistical difference of VAS score of various stage of operation,onset time of sensory block and block range between the two groups （P〉0.05）.The highest blocking plane time of the observation group was shorter than that in the control group （P〈 0.05）,the incidence rate of adverse reaction of the observation group was significantly lower than that in the control group （P〈0.05）. Conclusion 0.375% ropivacaine and 0.25% bupivacaine can be used for modified radical mastectomy safely.Ropivacaine has shorter induction time and wider safety range.

关 键 词：罗哌卡因 布比卡因 胸段硬膜外阻滞 乳腺癌改良根治术 

分 类 号：R737.9[医药卫生—肿瘤]