尿囊素对阿司匹林所致胃黏膜损伤大鼠胃黏膜血流及细胞因子的影响  

Effect of aldioxa on blood flow of gastric mucosa and cytokines in rats with aspirin-induced gastric mucosal injury

作　　者：乙国兴[1] 王洁[1] 崔梅花[1] 马志琳 戴立娜 

机构地区：[1]航天中心医院消化科,北京100049

出　　处：《现代医学》2015年第3期271-274,共4页Modern Medical Journal

基　　金：中华医学会北京分会消化专项科研资金资助项目(2009-001)

摘　　要：目的:通过观察尿囊素对阿司匹林所致急性胃黏膜损伤大鼠模型胃黏膜血流及细胞因子的影响,初步探讨尿囊素对胃黏膜保护的作用机制。方法:将60只健康雄性Wistar大鼠随机分成阿司匹林损伤组、空白对照组、硫糖铝保护组、氢氧化铝保护组、尿囊素保护组5组。保护组分别提前用硫糖铝、氢氧化铝、复方尿囊素给大鼠灌胃,其后用阿司匹林灌胃致急性胃黏膜损伤,然后分别测定各组大鼠的胃黏膜血流、胃黏膜前列腺素E2(PGE2)及一氧化氮(NO)的含量。结果:各保护组胃黏膜血流与阿司匹林损伤组比较明显增加,尿囊素保护组的胃黏膜血流明显高于氢氧化铝保护组(P=0.000),亦高于硫糖铝保护组,但差异无统计学意义(P=0.073)。尿囊素保护组及硫糖铝保护组胃黏膜PGE2及NO含量均较阿司匹林损伤组明显增加(P=0.001,P=0.000),尿囊素保护组的PGE2及NO含量均明显高于氢氧化铝保护组(P=0.004,P=0.007),亦高于硫糖铝保护组,但差异无统计学意义(P=0.085,P=0.352)。结论:尿囊素可增加阿司匹林致急性胃黏膜损伤大鼠的胃黏膜血流、胃黏膜PGE2及NO的含量,从而发挥胃黏膜保护作用。Objective： To study the potential pathogenesis of aldioxa tablets on aspirin-induced gastric mucosal lesions in rats＇ model. Methods： Sixty healthy male Wistar rats were randomly divided into five groups： injury group,control group,sucralfate protective group,aluminium hydroxide protective group,and aldioxa protective group. The three protective groups were treated with sucralfate, aluminium hydroxide and aldioxa tablets respectively before inducing gastric mucosal injury. Then the blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured. Results： In comparison with injury group,in aldioxa protective group the blood flow of gastric mucosa was significantly increased（ P = 0. 000）,prostaglandin E2 and nitric oxide concentration of gastric mucosa were also significantly increased（ P = 0. 001,P = 0. 000）.Conclusion： The data obtained revealed that aldioxa tablets can increase the blood flow,prostaglandin E2 and nitric oxide concentration of gastric mucosa in rats with acute gastric mucosa injury induced by aspirin,which may contribute to the mucosal protective effects.

关 键 词：尿囊素 阿司匹林 胃黏膜血流 前列腺素E2 一氧化氮 大鼠 

分 类 号：R-33[医药卫生] R965