正常老化过程中海马不同部位代谢物浓度与年龄的相关性  

Correlation between metabolite concentrations and age in different regions of hippocampus during normal brain aging

作　　者：常瑞亭[1] 耿左军[1] 朱青峰[1] 王亚[1] 韩学芳[1] 吕焕娣[1] 

机构地区：[1]河北医科大学第二医院医学影像科,河北石家庄050000

出　　处：《河北医科大学学报》2015年第3期291-295,共5页Journal of Hebei Medical University

基　　金：河北省医学科学研究重点课题(zd2013016)

摘　　要：目的利用氢质子磁共振波谱分析(1H magneticresonance spectroscopy,1H-MRS)技术,评价正常脑老化过程中双侧海马不同部位代谢物浓度的变化,并进一步探讨代谢物浓度与年龄的相关性。方法 121例健康右利手志愿者,行颅脑常规磁共振成像(magnetic resonance imaging,MRI)、磁共振波谱(magnetic resonance spectroscopy,MRS)检查,人为确定MRS感兴趣区,机器自动测量海马不同部位浓度值参数:N-乙酰天门冬氨酸(N-acetyl-aspartate,NAA)、胆碱(choline compounds,Cho)、肌酸(creatine,Cr)。比较不同性别、不同年龄组间各参数的差异。分析海马各部位NAA、Cho、Cr与年龄的相关性。结果不同性别间海马各部位NAA、Cho、Cr比较差异无统计学意义(P>0.05)。不同年龄组间双侧海马头、体(体1、体2)、尾部NAA值差异有统计学意义,老年组双侧海马头、体(体1区、体2区)、尾部NAA显著低于青年组和中年组(P<0.05),青年组与中年组比较差异无统计学意义(P>0.05);不同年龄组间Cho、Cr差异无统计学意义(P>0.05)。双侧海马头、体(体1、体2区)、尾部仅NAA与年龄呈负相关(P<0.05),Cho、Cr与年龄无相关性(P>0.05)。结论正常脑老化过程中海马各部位NAA值随年龄增长而降低,老年组明显低于青年组及中年组。海马各部位NAA、Cho、Cr值无性别差异。Objective To evaluate the metabolism change with aging brain in the different regions of the bilateral hippocampal using ~1H magnetic resonance spectroscopy（~1H-MRS）,and to further investigate the correlation between metabolites,metabolite concentrations ratio and age.Methods Brain conventional MRI,MRS were employed in 121 right-handed healthy volunteers.After selecting the regions of interest artificially,the required parameters N-acetyl-aspartate（NAA）,choline compounds（Cho）,creatine（Cr） were measured by the machine automatically.The parameters between genders and ages were compared.Pearson correlation analysis was used to further investigate the correlation between the concentrations of NAA,Cho,Cr and age in different regions of the hippocampus.Results No significant gender effects were found in the concentrations of NAA,Cho,Cr（P〈0.05）.A significant age effects were found in the concentrations of NAA in the hippocampal head,body（body 1 area,body 2 area） and tail.The concentrations of NAA in the above regions of elderly group decreased significantly as compared with young and elderly group（P〈0.05）,while NAA showed significant changes between young and middle aged group in the hippocampal head,body（body 1 area,body 2 area） and tail（P〉0.05）.No significant age-associated changes were observed in Cho,Cr.Only the NAA concentrations were negatively correlated with age in bilateral hippocampal head,body（body 1area,2 area）,and tail（P〉0.05）.No significant age-associated changes were observed in Cho,Cr（P〉0.05）.Conclusion The NAA concentration decreased with age in the different regions of the hippocampus during normal brain aging.The NAA concentration in elderly group is significantly lower than that of young and middle aged group.No significant differences are found in the concentrations of NAA,Cho,Cr between genders.

关 键 词：氢质子波谱成像 海马 脑老化 相关性分析 

分 类 号：R735.7[医药卫生—肿瘤]