分子病理学技术在肿瘤诊治中的应用  

The application of molecular pathological technology in the diagnosis and treatment of tumors

作　　者：董贺[1] 孙青[1] 

机构地区：[1]山东大学附属千佛山医院病理科,山东济南250014

出　　处：《分子诊断与治疗杂志》2015年第2期73-77,82,共6页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81272420);山东省科技发展计划(2011GSF11838);山东自然科学基金(2R2012HM085);济南市科技发展计划项目(201202039)

摘　　要：近几十年来,新兴学科——分子病理学的出现,使得人类对疾病特别是肿瘤的研究从器官、组织、细胞水平深入到蛋白、染色体和DNA水平。这不仅能为病理诊断提供更准确、更客观的依据,且可更好地指导肿瘤的靶向治疗和预后判断等,极大地推动了病理学的发展。分子病理学的技术如免疫组化、原位杂交、基因突变检测、生物芯片、流式细胞术等,已经得到了广泛应用,并将在未来的医疗领域里扮演越来越重要的角色。本文就近年来分子病理学技术在肿瘤诊治中的应用进行综述。In recent decades, the development of molecular pathology has deepen people＇s knowledge of disease and tumor from the level of organ, tissue, cell to the level of protein, chromosome and DNA. The molecular pathological technology has greatly promoted the development of modem pathology by providing more precisive and objective evidence to guide the target therapy and prognosis of tumors. Molecular pathological technology has been widely applied, such as immunohistochemistry, in situ hybridization, gene mutation detection, biochips, flow cytometry and so on. The molecular pathology will play a more and more important role in the future medical treatment. Here we summarize the application of molecular pathology technology in recent years in the diagnosis and treatment of tumors.

关 键 词：分子病理学技术 肿瘤诊治 

分 类 号：R730.43[医药卫生—肿瘤]