青少年网络游戏成瘾者脑灌注的改变  

Abnormalities of Perfusion in Adolescents with Internet Gaming Addiction

作　　者：李磊[1] 陈雪[1] 孙锦华[2] 孙雅文[1] 庄治国[1] 丁伟娜[1] 周滟[1] 许建荣[1] 杜亚松[2] 

机构地区：[1]上海交通大学医学院附属仁济医院放射科 [2]上海交通大学医学院附属上海精神卫生中心青少年心理健康中心

出　　处：《中国医学计算机成像杂志》2015年第1期11-15,共5页Chinese Computed Medical Imaging

基　　金：国家自然科学基金No.81171325;国家自然科学基金No.81201172;上海市科委医学引导项目No.114119a0900~~

摘　　要：目的:运用动脉自旋标记成像对青少年网络游戏瘾(IGA)患者的脑血流量(CBF)改变进行研究。方法:18名IGA及17名健康被试进行MRI扫描,进行基于体素的两组CBF比较。运用陈氏网络成瘾量表评分(CIAS)与18名IGA被试的全脑各区域的CBF值进行相关分析。结果:IGA组右侧颞上回、右侧额眶回、右侧豆状核、左侧扣带回、左侧豆状核/海马旁回、左侧颞中回、左侧中央前回、脑干左侧和左侧直回较对照组CBF明显增高;右侧颞上回CBF值与CI AS评分负相关。结论:本研究通过ASL技术无创地对IGA被试脑灌注改变进行了定量分析,实验结果验证了IGA作为一种行为成瘾,与物质成瘾可能具有相似的神经生物学机制的假说。Purpose： We used pseudocontinuous arterial spin-labeling （ASL） perfusion functional magnetic resonance imaging （fMRI） to measure the effects of internet gaming addiction （IGA） on resting brain functions by comparing resting cerebral blood flow （CBF） in adolescents with IGA and normal subjects. Methods： Eighteen adolescents with IGA and 17 matched normal adolescents underwent fMRI scans. Direct subtraction, voxel-wise general linear modeling was performed to compare resting CBF between the 2 groups. Correlations were calculated between the Chen Internet Addiction Scale （CIAS） scores and the CBF value within the whole brain in the 18 subjects with IGA. Results： Compared with control subjects, adolescents with IGA showed significantly higher global CBF in the right superior temporal gyrus, right orbitofrontal gyrus, right putamen, left cingulate gyrus, left putamen/parahippocampa gyrus, left middle temporal gyrus, left precentral gyrus, left brainstem and left rectal gyrus. There was significant negative correlation between CBF values in right superior temporal gyrus and the CIAS scores in the IGA group. Conclusion： In this study, we used ASL perfusion fMRI and noninvasively quantified resting CBF to demonstrate that IGA alters the CBF distribution in the adolescent brain. The results support the hypothesis that IGA is a behavioral addiction that may share similar neurobiological abnormalities with other addictive disorders.

关 键 词：网络游戏成瘾 动脉自旋标记灌注成像 功能磁共振 脑血流量 

分 类 号：R445.2[医药卫生—影像医学与核医学]