幽门螺杆菌所致复发性口腔溃疡与消化系溃疡的相关性  

Association between recurrent oral ulcers and gastrointestinal ulcers caused by Helicobacter pylori infection

作　　者：陈丹宇[1] 王铿[2] 

机构地区：[1]海南医学院附属医院口腔科,海南省海口市570102 [2]海南医学院附属医院消化内科,海南省海口市570102

出　　处：《世界华人消化杂志》2015年第6期1028-1031,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与复发性口腔溃疡、消化系溃疡的临床相关性.方法:选取2012-01/2013-12海南医学院附属医院110例复发性口腔溃疡患者为A组,120例消化系溃疡患者为B组,检测两组唾液与胃黏膜H.pylori的情况,分析其相关性.结果:A组vs B组胃黏膜中的H.pylori检出率(45.5%vs 94.2%),差异有统计学意义;浅表或者糜烂胃炎、复合溃疡和胃溃疡以及十二指肠溃疡胃内vs口腔H.pylori检出率(93.3%、100.0%、90.0%、95.6%vs51.7%、60.0%、60.0%、20.0%),差异有统计学意义(P<0.05).结论:口腔、消化系之间的H.pylori具有相互转移的情况,而复发性口腔溃疡口腔H pylori感染是否导致消化系溃疡的发生与再感染需要临床中进一步的试验研究.AIM： To investigate the relevance among Helicobacter pylori （H. pylori） infection, recurrent oral ulcers and peptic ulcers. METHODS： One hundred and ten patients with recurrent oral ulcers （group A） and 120 patientswith peptic ulcers treated at our hospital from January 2012 to December 2013 were included. H. pylori status in the saliva and gastric mucosa was detected, and association among H. pylori infection, recurrent oral ulcers and peptic ulcers was then analyzed. RESULTS： The rate of H. pylori infection in the gastric mucosa was 45.5% in group A and 94.2% in group B （P 〈 0.05）. The rates of H. pylori infection in the gastric mucosa in patients with superficial or erosive gastritis, gastric ulcers, duodenal ulcers and complex ulcers were 93.3%, 100.0%, 90.0%, and 95.6%, respectively, and the corresponding rates in the saliva were 51.7%, 60.0%, 60.0%, and 20.0% （P 〈 0.05）. CONCLUSION： There is a possible link between H. pylori infection in the mouse and in the gastrointestinal tract, and whether recurrent oral ulcers caused by H. pylori infection causes gastrointestinal ulcers needs to be further studied.

关 键 词：幽门螺杆菌 复发性口腔溃疡 消化系溃疡 相关性 

分 类 号：R781.5[医药卫生—口腔医学]