学龄前儿童孤独症杏仁核的MRI表现及临床研究  

MRI Finding of Amygdala in Preschool Children with Autism and Its Relationship with Clinical Manifestations

作　　者：朱宗明[1] 汤群锋[1] 翟晓东[1] 方向明[1] 吴力源[1] 邹兴农[1] 陈寅[1] 华妙强[1] 陈宏伟[1] 

机构地区：[1]南京医科大学附属无锡人民医院医学影像科,无锡214023

出　　处：《临床放射学杂志》2015年第2期263-266,共4页Journal of Clinical Radiology

摘　　要：目的测量学龄前儿童孤独症的杏仁核体积,分析学龄前儿童孤独症(Autism)杏仁核体积、MRI信号特点并与相应的临床特征进行相关性研究。方法搜集43例经我院临床确诊孤独症的学龄前儿童及同期15例与之年龄匹配的健康儿童(对照组),使用3.0 T MRI进行脑部扫描,选择斜冠状位T1WI序列对实验对象杏仁核体积进行测量,并分析孤独症组杏仁核的信号特点,对孤独症组和对照组杏仁核的体积对比进行统计学分析,对孤独症组的杏仁核体积与临床特征进行相关性分析。以上受试儿童扫描前均口服10%水合氯醛镇静。结果 43例孤独症组,1例双侧杏仁核信号均发现异常,5例右侧杏仁核信号异常,14例左侧杏仁核信号异常,MRI表现为T1WI杏仁核内呈点片状低信号或等低信号、等高或高信号;右侧杏仁核体积平均为(1.11±0.41)cm3,左侧杏仁核体积平均为(1.06±0.43)cm3,左右杏仁核体积比较差异无统计学意义(t=0.60,P=0.55>0.05);15例对照组中,右侧杏仁核体积平均为(0.72±0.25)cm3,左侧杏仁核体积平均为(0.62±0.23)cm3。孤独症组与对照组杏仁核左侧(t=3.71,P<0.001)、右侧(t=3.45,P<0.001)体积分别比较,差异均有统计学意义;右侧杏仁核平均体积与年龄呈显著正相关关系(r=0.42,P=0.01)。结论学龄前儿童孤独症的双侧杏仁核体积均较正常儿童增大,杏仁核内可出现异常信号,学龄前儿童孤独症右侧杏仁核平均体积增大与年龄增长有较为密切关系。Objective To estimate amygdala volume in preschool children with autism and to explore the relationship between amygdala volume, MRI findings and clinical features. Methods A total of 43 preschool children with clinically- confirmed autism （study group） and 15 age-matched healthy children （control group） were enrolled in this study. MRI scan of the brain was performed in all subjects by using a 3.0 T MRI scanner. The oblique coronal T1 WI sequence was used to measure the volume of amygdala; the amygdala signal characteristics of the study group were analyzed; the amygda- la volumes were compared between the two groups; and the relationship between amygdala volume and clinical features were analyzed. Before MRI scan all subjects orally received 10% chloral hydrate to get sedation. Results Among 43 autism children, abnormal signal in bilateral amygdalas was observed in one, abnormal signal in right amygdala in 5 and abnormal signal in left amygdala in 14. MRI revealed that the lesions of amygdala presented as punctuate or flaky lower or iso-lower signal, or iso-higher or higher signal on Tl WI images. The average volume of the right and the left amygdala was （ 1.11± 0.41 ） em3 and （ 1.06 ± 0.43 ） cm3 respectively; the difference in the average volume between the right and the left amyg- dala was not statistically significant （ t = 0. 60, P = 0.55 〉 0.05 ）. In the control group, the mean volume of the fight and left amygdala was （0.72 ± 0.25 ） cm3 and （0.62 ± 0.23 ） cm3 respectively. Statistically significant difference in the mean volume of the left （ t = 3.71, P 〈 0. 001 ） and right （ t = 3.45, P 〈 0. 001 ） amygdala existed between the study group and the control group. The mean volume of the right amygdala had a parallel relationship with the age （ r = 0. 42, P = 0.01 ）. Conclusion The volume of bilateral amygdala in preschool children with autism is larger than that in normal children. In preschool children with autism, abnormal signal can be observed in amygdala

关 键 词：学龄前儿童 孤独症 杏仁核 磁共振成像 体积 信号 

分 类 号：R749.94[医药卫生—神经病学与精神病学]