降钙素原对脓毒症鉴别诊断及预后监测的方法评价  

The clinical value of procalcitonin for sepsis in differential diagnosis and prognostic monitoring

作　　者：张天卿[1] 沈淑男[2] 胡哲清[1] 

机构地区：[1]慈溪市人民医院ICU科,宁波315300 [2]慈溪市人民医院学生办公室,宁波315300

出　　处：《中华实验和临床病毒学杂志》2015年第1期87-89,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：浙江省卫生科技计划项目（2014KYB246）

摘　　要：目的 评价血清降钙素原（PCT）在脓毒症鉴别诊断及预后监测的价值.方法 76例脓毒症患者,其中早期脓毒症43例,严重脓毒症患者20例,脓毒症休克患者13例.采用免疫荧光法检测血清中PCT和CRP水平.结果 脓毒症休克组与严重脓毒症组相比、严重脓毒症组和早期脓毒症组相比,PCT、CRP、APACHE Ⅱ评分之间均有统计学意义（P＜0.05）;脓毒症患者血清PCT与APACHEⅡ评分之间存在显著正相关（r=0.57,P＜0.05）;在使用抗生素治疗后血清PCT可快速下降,出院前恢复到正常水平,而CRP在细菌感染被控制后仍维持在高水平,出院前浓度仍高于正常水平,其回落速度慢于血清PCT.结论对于鉴别不同程度的脓毒症,PCT是一个很好的血清指标,还可进行脓毒症预后的监测.Objective Evaluation of serum procalcitonin （PCT） in sepsis differential diagnosis and prognostic monitoring value.Methods 76 cases of sepsis patients,including 43 cases of early sepsis,severe sepsis patients in 20 cases,13 cases of patients with septic shock.Immunofluorescence is used on the detection of serum PCT and CRP levels.Results Septic shock group compared with severe sepsis,severe sepsis group compared with early sepsis group,PCT,CRP,APACHE Ⅱ was statistically significant （P 〈 0.05） ; there is a significant positive correlation between sepsis patients serum PCT and APACHE Ⅱ score （r =0.57,P 〈 0.05）; after antibiotic treatment,serum PCT can be decreased rapidly,before discharge returned to normal levels,while the CRP after being controlled is still maintained at a high level,before discharge concentration was still higher than normal level,slowly than serum PCT.Conclusion For the identification of different degree of sepsis,PCT is a good index for monitoring the serum,also can make the sepsis prognosis.

关 键 词：降钙素 脓毒症 预后 

分 类 号：R459.7[医药卫生—急诊医学]