高尔基体糖蛋白73联合甲胎蛋白L3诊断原发性肝癌的荟萃分析  

Diagnostic value of serum Golgi protein-73 （GP73） combined with AFP-L3% in hepatocellular carcinoma： a meta-analysis

作　　者：施明明[1] 黄桢翔 杨月[1] 赵本华[1] 

机构地区：[1]厦门大学公共卫生学院,361100

出　　处：《中华肝脏病杂志》2015年第3期189-193,共5页Chinese Journal of Hepatology

摘　　要：目的 采用Meta分析方法系统评价血清标志物高尔基体糖蛋白73 （GP-73）联合甲胎蛋白异质体L3 （AFP-L3）在原发性肝癌中的诊断意义. 方法 计算机结合手工检索查阅所有公开发表的GP-73联合AFP-L3％诊断原发性肝癌的文献.依据纳入及排除标准对文献进行筛选,对纳入文献进行数据提取,采用mem-disc1.4和stata12.0软件进行统计分析. 结果 从138篇文献中筛选出11篇符合纳入标准的研究.异质性检验提示GP-73联合AFP-L3％诊断不存在阈值效应,但存在其他原因引起的异质性,故采用随机效应模型合并效应量.结果显示GP-73联合AFP-L3％诊断原发性肝癌的总灵敏度为0.853 （95％CI：0.833 ～ 0.872）,总特异度为0.960 （95％CI：0.960 ～ 0.968）.两者联合的综合受试者工作曲线下面积为0.948,Q指数为0.888.结论 GP-73联合AFP-L3％诊断原发性肝癌的灵敏度与特异度均保持较高水平,临床可应用该联合诊断指标进行原发性肝癌的早期诊断.Objective To investigate the diagnostic value of serum Golgi protein-73 （GP73） combined with the AFP-L3% test for hepatocellular carcinoma.Methods Comprehensive electronic and manual searches were performed to retrieve relevant studies on GP73 combined with AFP-L3% for diagnosis of hepatocellular carcinoma.After screening of the studies according to inclusion criteria and extraction of the data,meta-analysis was performed in Meta-disc 1.4 and Stata 12.0.Results Eleven studies that met the inclusion criteria were selected from the total 138 references with potential relevance.The threshold effect was not found in the GP73 combined with AFP-L3% for the diagnosis of liver cancer.However,heterogeneity was found in this meta-analysis.The pooled sensitivity and specificity of GP73 combined with AFP-L3% was 0.853 and 0.960 respectively.The area under summary receiver operating characteristics curve was 0.948,and the Q index was 0.888.Conclusion GP73 combined with AFP-L3% can significantly improve the diagnostic sensitivity and specificity to a high level,and can improve the diagnosis rate of hepatocellular carcinoma.

关 键 词：肝肿瘤 甲胎蛋白类 META分析 

分 类 号：R735.7[医药卫生—肿瘤]