原发性胆汁性肝硬化发病机制研究的应用前景  

Application prospects of research on pathogenesis of primary biliary cirrhosis

作　　者：卢芳汀[1] 廉哲雄[1] 

机构地区：[1]中国科学技术大学生命科学学院肝脏免疫学实验室,合肥230026

出　　处：《临床肝胆病杂志》2015年第2期153-156,共4页Journal of Clinical Hepatology

摘　　要：原发性胆汁性肝硬化是一种以肝内小胆管损伤为特征的自身免疫性肝病,该疾病的发生发展是极其复杂的自身免疫反应过程,众多的免疫细胞和免疫分子参与其中。从天然免疫以及适应性免疫两个方面,在细胞以及分子层面对PBC发病机制的研究进展进行总结,并对该发病机制研究的临床应用前景进行评述,以期能够为该疾病研究领域的科研及临床工作者提供参考方向并为临床诊断和治疗新方案的提出提供理论依据。Primary biliary cirrhosis （PBC） is an autoimmune liver disease characterized by the destruction of small intrahepatic bile ducts. Incomprehensible and complicated autoreactive responses participate in the development and progression of PBC, which involve various im- mune cells and inflammatory mediators. Based on the aspects of innate immunity and adaptive immunity, this article summarizes recent ad- vances in the research on PBC pathogenesis at cellular and molecular levels and evaluates the clinical application of these studies. This arti- cle not only gives a feasible direction for researchers and clinicians in this study field, but also provides a theoretical basis for clinical diagno- sis and novel therapeutic strategies.

关 键 词：肝硬化 胆汁性 免疫 天然 免疫法 被动 述评 

分 类 号：R575.22[医药卫生—消化系统]