肝纤维化非创伤性诊断的新近认识  

Recent research findings on non-invasive diagnosis of liver fibrosis

作　　者：武琼[1] 徐光华[1] 

机构地区：[1]延安大学附属医院感染科,陕西延安716000

出　　处：《临床肝胆病杂志》2015年第2期295-299,共5页Journal of Clinical Hepatology

摘　　要：对肝纤维化做出早期诊断,并动态监测其变化,对于慢性肝病的治疗及改善预后有着重要的意义。目前肝纤维化的诊断和分期的"金标准"仍是肝穿刺活组织病理检查,但因其局限性,近年来人们一直致力于寻找更准确的非创伤性的诊断方法。这些方法包括:血清纤维化标志物和数学模型、超声、超声定量、超声弹性成像技术、CT、磁共振成像(MRI)、核医学,总结了各种方法的优缺点,对其临床使用的合理选用及如何相互对照验证进行了分析。认为未来的方向可能是将上述检测方法进行联合检测和综合评估,以提高肝纤维化非创伤性诊断的临床使用价值。Early diagnosis of liver fibrosis and dynamic monitoring of relevant changes have great implications for the treatment and prognosis improvement of chronic liver diseases. So far, liver biopsy remains the “golden standard” for the diagnosis and staging of liver fibrosis. How- ever, due to its inherent limitations, a great effort has been made to develop more accurate non - invasive diagnostic methods, including ser- um fibrosis markers and mathematical models, ultrasound, contrast - enhanced ultrasonography, ultrasonic elastography, computed tomo- graphy, magnetic resonance imaging, and nuclear medicine. The advantages and disadvantages of relevant methods are discussed. Further- more, proper selection of the non - invasive diagnostic methods for clinical application and the means for mutual verification are analyzed. As for the future direction, it is expected to employ the above methods for combined analysis and comprehensive assessment, in order to enhance the clinical value of non - invasive liver fibrosis diagnosis.

关 键 词：肝硬化 非创伤性检查 诊断 综述 

分 类 号：R575.2[医药卫生—消化系统]