α-硫辛酸对偏头痛疗效的临床研究  

Efficacy assessment of α-thioctic acid on episodic migraine

作　　者：李超[1] 王凤志[1] 何秋[1] 侯爱洁[2] 

机构地区：[1]辽宁省人民医院神经内科,沈阳110016 [2]辽宁省人民医院心脏中心,沈阳110016

出　　处：《实用药物与临床》2015年第3期345-347,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察α-硫辛酸对偏头痛防治的临床效果。方法采用随机对照的实验方法。将纳入的42例偏头痛患者随机分为硫辛酸组(20例)和对照组(22例)。硫辛酸组口服α-硫辛酸及氟桂利嗪,对照组口服氟桂利嗪。治疗持续4周,观察两组患者治疗前后头痛发作频率、头痛程度、头痛持续时间及超敏C-反应蛋白(hs-CRP)的变化。结果硫辛酸组及对照组的临床有效率分别为80%和45%,两组疗效比较差异有统计学意义(P<0.05)。与硫辛酸组治疗前及对照组治疗后相比,硫辛酸组治疗后头痛发作频率及hs-CRP值降低,头痛持续时间缩短,头痛程度减轻,组内及组间比较差异均有统计学意义(P<0.05)。在研究过程未发生严重不良反应。结论α-硫辛酸防治偏头痛疗效确切,安全可靠。Objective To investigate the effect of a-thioctic acid on episodic migraine.Methods 42 patients with episodic migraine were recruited and randomly divided into a-thioctic acid group and control group.The two groups received either α-thioctic acid capsule and flunarine capsule（n = 20） or flunarine capsule（n = 22） for 4weeks.The frequency,severity and duration of headache were observed,and hypersensitive C-reactive protein（hs-CRP）was tested before and after treatment.Results Within-group analysis showed a significant reduction of frequency,duration,severity of headache and C--reaction protein levels in α-thioctic acid group（P 0.05）.There were significant differences in frequency of headache index and hs-CRP levels between a-thioctic acid group and control group after treatment（P 0.05）.No adverse effect was reported.Conclusion The therapy of a-thioctic acid on migraine is effective and safe.

关 键 词：偏头痛 Α-硫辛酸 超敏C-反应蛋白 

分 类 号：R747.2[医药卫生—神经病学与精神病学]