恶性肿瘤患者化疗前后免疫活性细胞的变化及临床意义  

THE CHANGE AND CLINICAL SIGNIFICANCE OF IMMUNE ACTIVITED CELLS BEFORE AND AFTER CHEMOTHERAPY IN MALIGNANT CARCINOMA PATIENTS

作　　者：王亚兰[1] 王丽[1] 

机构地区：[1]包头市第七医院,内蒙古包头014030

出　　处：《肿瘤研究与临床》2002年第4期251-252,共2页Cancer Research and Clinic

摘　　要：目的 :探讨恶性肿瘤患者免疫活性细胞在抗瘤药治疗前后的变化。方法 :采用流式细胞仪对 5 0例恶性肿瘤患者化疗前后免疫活性细胞进行监测。结果 :化疗前 CD+ 3、CD+ 4、CD+ 8及 NK细胞明显降低 ,B细胞明显增高 ,化疗后 CD+ 3、CD+ 4显著增高 ,几乎达到正常对照 ,而 NK细胞进一步降低 ,B细胞则进一步增高 ,CD+ 4/ CD+ 8比例化疗前与正常对照组无显著差异 ,化疗后则明显增高 ,并超出正常范围。结论 :恶性肿瘤患者细胞免疫功能处于抑制状态 ,体液免疫功能增强。抗肿瘤药物对机体免疫功能造成部分损害 ,而总的免疫功能提高 ,化疗配合免疫治疗可增强肿瘤治疗的疗效。Objective:To explore the change and significance between before and after chemotherapy with immune activited cell in malignant carcinoma patients.Methods:We use flow cytometer to test the immune activity cells.Results:Before chemotherapy,CD + 3,CD + 4,CD + 8,and NK cells significantly reduced.B cell was significantly higher.At the end of chemotherapy,CD + 3,CD + 4 cells were significantly higher.It almost can attain to normal levels, but NK cell progressively reduced.B cell progressed higher before chemotherapy. CD + 4/CD + 8 was equal to healthy controls, and at the end of chemotherapy CD + 4/CD + 8 was significantly higher than the normal levels.Conclusion:In patients of malignant carcinoma cell immunity was immunosuppressed,but bodyfluid immunity enhanced. The anti carcinoma drug only damage physical immunity partly, but the whole immunity was risen.Therefore, chemotherapy combine with biology therapy can enhance efficiency of carcinoma treatment. It obviously improved the survival rate and life quality.

关 键 词：恶性肿瘤 T淋巴细胞亚群 B淋巴细胞亚群 自然杀伤细胞 化疗 流式细胞术 

分 类 号：R730.53[医药卫生—肿瘤] R730.3[医药卫生—临床医学]