Th17 Cells in autoimmune diseases  

作　　者：Lei Han Jing Yang Xiuwen Wang Dan Li Ling Lv Bin Li 

机构地区：[1]Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, China [2]Key Laboratory of Molecular Virology and Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Frontiers of Medicine》2015年第1期10-19,共10页医学前沿（英文版）

基　　金：Our research is supported by the National Basic Research Program of China （2014CB541803, 2014CB541903）, National Natural Science Foundation of China （81330072, 31370863, 31200647, 81271835）, National Science and Technology Major Project （2012ZX10002007-003）, and STCSM project （14JC1406100）.

摘　　要：Th17 cells are a new subset of CD4^＋ T cells fungi. Accumulating evidence suggests that Tb17 cells involved in the clearance of extracellular pathogens and and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren＇s syndrome, inflammatory bowel disease, and multiple sclerosis.Th17 cells are a new subset of CD4^＋ T cells fungi. Accumulating evidence suggests that Tb17 cells involved in the clearance of extracellular pathogens and and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren＇s syndrome, inflammatory bowel disease, and multiple sclerosis.

关 键 词：IL-17 Thl 7 cells RORΓT autoimmune diseases posttranslational modification INHIBITORS 

分 类 号：Q2[生物学—细胞生物学] S858.31[农业科学—临床兽医学]