A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy  

作　　者：Xiaolong Wei Chunfa Chen Didi Xi Jinwen Bai Wenhe Huang Luoxiang Rong Mingyao Wu Guojun Zhang 

机构地区：[1]Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China [2]Cancer Research Center, Shantou University Medical College, Shantou 515031, China [3]The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515031, China [4]Department of Pathology, Shantou University Medical College, Shantou 515031, China

出　　处：《Frontiers of Medicine》2015年第1期112-116,共5页医学前沿（英文版）

基　　金：This study is partly supported by the National Basic Research Program of China （973 Program, Grant No. 2011CB707705）, the National Natural Science Foundation of China （Grant Nos. 31271068 and 81302331）, and Guangdong Provincial Key Laboratory on Breast Cancer Diagnosis and Treatment Research.

摘　　要：Primary neuroendocrine breast carcinoma （NEBC） is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy （partial response based on RECIST criteria） and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.Primary neuroendocrine breast carcinoma （NEBC） is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy （partial response based on RECIST criteria） and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.

关 键 词：neuroendocrine carcinoma neo-adjuvant therapy BREAST 

分 类 号：S816.7[农业科学—饲料科学] S858.292[农业科学—畜牧学]