18F-L-DOPA PET/CT显像诊断先天性高胰岛素血症的研究进展  

Research progress of 18F-L-DOPA PET/CT in the diagnosis of congenital hyperinsulinism

作　　者：任静芸 杨吉刚[1] 

机构地区：[1]首都医科大学附属北京友谊医院核医学科,100050

出　　处：《国际放射医学核医学杂志》2015年第1期67-70,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81101069）;2012年北京市卫生系统“十百千”卫生人才“百”层次人选（2013-3-066）

摘　　要：先天性高胰岛素血症（CHI）是由于胰腺β细胞分泌过多的胰岛素导致顽固性的低血糖及与血糖水平不相称的相对高胰岛素血症。CHI的治疗方法包括内科治疗和外科手术治疗，对于内科治疗无效或效果不佳的患者常需要外科手术治疗。CHI主要分为局灶型和弥漫型，局灶型CHI可通过外科手术切除病灶而治愈，弥漫型CHI需进行胰腺次全切除术治疗。因此，手术治疗前明确病理类型至关重要。CT、MRI及超声等影像学检查对于鉴别局灶型与弥漫型CHI具有一定的局限性，而18F-左旋多巴PET/CT显像具有一定优势。笔者对18F-左旋多巴PET/CT显像诊断CHI进行了综述，对临床实践具有一定的指导意义。Congenital hyperinsulinism （ CHI ） is a condition leading to recurrent hypoglycemia due to an inappropriate insulin secretion by the pancreatic isletβcells. There are two main histologic sub-types： diffuse and focal, which may require different treatment strategies. Patients with diffuse CHI dis-ease require a neartotal pancreatectomy. However patients with focal CHI disease only require a limited pancreatectomy to remove only the focal lesion thus providing complete cure to the patient. Hence the pre-operative diagnosis of the histological subtypes of CHI becomes paramountin during the management of CHI. There was no advantages of morphological imaging methods, such as CT and MRI, in the differential diagnosis of focal and diffuse CHI. The CHI patient should perform 18Fluoride-L-dihydroxyphenylalanine （18F-L-DOPA） PET scan to differentiate focal from diffuse lesion, which can provide guidance for operation. This paper reviewed the research progress of 18F-L-DOPA PET scan in the diagnosis of CHI in recent years.

关 键 词：先天性高胰岛素血症 左旋多巴 正电子发射断层扫描术 体层摄影术 X线计算机 

分 类 号：R587[医药卫生—内分泌] R817.4[医药卫生—内科学]