18F-氟化钠P ET/CT诊断肿瘤骨转移应用进展  

Application progress of 18F-NaF PET/CT in the diagnosis of neoplasm metastases

作　　者：张胤[1] 陈跃[1] 

机构地区：[1]四川泸州医学院附属医院核医学科,646000

出　　处：《国际放射医学核医学杂志》2015年第1期96-102,共7页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：18F-氟化钠（18F-NaF）作为骨扫描示踪剂已有50多年的历史，期间由于正电子探测器的缺乏等因素被99Tcm-MDP替代。随着PET/CT的发展，将18F-NaF作为PET/CT示踪剂的研究逐渐增多。18F-NaF本身的药物特性以及PET/CT相对于SPECT/CT的优势，使得18F-NaF PET/CT诊断恶性肿瘤骨转移的灵敏度、特异度优于99Tcm-MDP骨扫描。与99Tcm-MDP骨显像、18F-FDG PET/CT和MRI相比，18F-NaF PET/CT在诊断恶性肿瘤骨转移时具有更高的灵敏度，并且对于不同肿瘤的骨转移有不同的诊断价值。18F-NaF联合18F-FDG PET/CT扫描被证明具有一定的应用价值。18F-NaF PET/CT是诊断恶性肿瘤骨转移的安全、有效、简便、无创的方法。18F-NaF has been used for the tracer of bone scans more than 50 years. After a period of decline for the shortage of positron detector, scholars using 18F-NaF as radioactive tracer is increasing with the development of PET/CT. The natural medicinal property of 18F-NaF and the advantage of PET make the 18F-NaF PET/CT a better way to assess malignant osseous metastases than 99Tcm-MDP bone scan in sensitivity and specificity. When compared with 99Tcm-MDP bone scan, 18F-FDG PET/CT and magnetic resonance imaging, 18F-NaF PET/CT has higher sensitivity in detecting osseous metastases of malignancies. 18F-NaF PET/CT also has different diagnostic values in management of patients with malignancies. Combine 18F-NaF and 18F-FDG in one PET/CT examination is proven to have potential in clinical management. 18F-NaF PET/CT is a safe, effective, simple and noninvasive method in diagnosis of bone metastases in malignant tumor.

关 键 词：氟化钠 骨 肿瘤转移 正电子发射断层显像术 体层摄影术 X线计算机 氟放射性同位素 

分 类 号：R738.1[医药卫生—肿瘤]