依达拉奉对急性脑梗死患者日常生活能力和神经功能的影响  

Effect of Edaravone on the Nerve Function and Activity of Daily Living in Patients with Acute Cerebral Infarction

作　　者：雷华[1] 张明 

机构地区：[1]重庆市涪陵中心医院神经内科,重庆涪陵区408000 [2]重庆市西南医院,重庆402283

出　　处：《河北医学》2015年第5期752-754,共3页Hebei Medicine

基　　金：中国高校医学期刊临床专项资金项目;(编号:11231109)

摘　　要：目的:探讨依达拉奉对急性脑梗死患者日常生活能力和神经功能的影响,改善患者预后。方法:选择符合标准的患者86例,随机分为观察组44例和对照组42例,均按急性脑梗死常规治疗,观察组加用依达拉奉,治疗前后采用日常生活活动能力量表(Barthel Index)及美国国立卫生研究院脑卒中量表(NIHSS)进行评定治疗效果。结果:两组患者治疗前Barthel Index及NIHSS评分相似,差异无统计学意义(P>0.05);治疗7 d、14 d后,两组患者Barthel Index评分较治疗前均升高,NIHSS评分较治疗前均降低,但是观察组患者改善幅度更显著,差异有统计学意义(P<0.05)。观察组患者基本痊愈12例、好转21例、进步8例和无效3例;对照组患者基本痊愈8例、好转14例、进步12例和无效8例,差异有统计学意义(P<0.05)。结论:依达拉奉可以有效降低急性脑梗死患者神经功能缺损程度,提高日常生活活动能力,改善患者预后。Objective： To investigate the effect of edaravone on the nerve function and activity of daily living in patients with acute cerebral infarction,and to improve the prognosis. Method： A total of 86 eligible patients were selected and randomly divided into observation group and control group,with 44 patients in the observation group and 42 patients in the control group. All the patients were given with conventional therapy for acute cerebral infarction,but the observation group were given with edaravone additionally,and the preand post-treatment effectiveness was evaluated according to activity of daily living scale（ Barthel Index） and（ America） national institutes of health stroke scale（ NIHSS）. Result： Before the treatment,the patients of the two groups had similar Barthel Index and NIHSS scores,and the differences were statistically insignificant（ P〉0.05）. On 7 days and 14 days after the treatment,the patients of both groups had increased Barthel Index scores and decreased NIHSS scores when compared with those before the treatments,but the patients of the observation group had greater improving extents,and the differences were statistically significant（ P〈0.05）. Of the observation group,12 patients were basically cured,21 patients got significantly improved,8patients got slightly improved,and 3 patients were unresponsive to the treatment; while of the control group,8 patients were basically cured,14 patients got significantly improved,12 patients got slightly improved,and8 patients were unresponsive to the treatment; the difference was statistically significant（ P〈0.05）. Conclusion： Edaravone can effectively lighten the neurologic impairment,elevate activities of daily living,and improve the prognosis in patients with acute cerebral infarction.

关 键 词：依达拉奉 急性脑梗死 神经功能 日常生活能力 

分 类 号：R743.3[医药卫生—神经病学与精神病学]