大蒜素对空肠弯曲杆菌抑菌作用的研究  

Study on anti-microbial activity of allicin on campylobacterjejuni

作　　者：潘洪涛[1] 杨宗兴[1] 赵文萃[1] 王艳萍[1] 宋海艳[1,2] 张琦[1] 

机构地区：[1]解放军208医院,吉林长春130062 [2]延边大学药学院,吉林延吉133000

出　　处：《药学实践杂志》2015年第2期147-149,170,共4页Journal of Pharmaceutical Practice

摘　　要：目的研究大蒜素对空肠弯曲杆菌的抑菌作用和强度。方法采用纸片扩散法(K-B法)测定抑菌圈直径;采用肉汤稀释法分别测定大蒜素、环丙沙星、红霉素对空肠弯曲杆菌的最低抑菌浓度(MIC),比较大蒜素、环丙沙星、红霉素的最低抑菌浓度及抑菌率。结果大蒜素(MIC为12.80μg/ml,抑菌率90.40%)对空肠弯曲杆菌的抑菌作用较环丙沙星(MIC为20.48μg/ml,抑菌率90.21%)和红霉素(MIC为35.84μg/ml,抑菌率90.33%)更强。结论大蒜素对空肠弯曲杆菌具有抑菌作用。Objective To study the anti‐microbial activity and strength of allicin on Campylobacter jejuni .Methods Disc diffusion method （K‐B） was used to determine the diameter of the bacteriostatic ring .The minimal inhibitory concentra‐tion （MIC） of allicin ,ciprofloxacin and erythromycin were detected by constant broth dilution method ,respectively .The mini‐mal inhibitory concentrations and bacteriostatic rate of allicin ,ciprofloxacin and erythromycin were compared .Results The anti‐microbial activity on Campylobacter jejuni of allicin （MIC 12 .8 μg/ml ,bactetiostatic rate 90 .40% ） was better than that of ciprofloxacin （MIC 20 .48 μg/ml ,bactetiostatic rate 90 .21% ） and erythromycin （MIC 35 .84 μg/ml ,bactetiostatic rate 90 . 33% ） .Conclusion Allicin has anti‐microbial activity on Campylobacter jejuni in vitro .

关 键 词：大蒜素 环丙沙星 红霉素 最低抑菌浓度 抑菌率 

分 类 号：R96[医药卫生—药理学]