环状脱氢氨基酸及其衍生物的不对称催化氢化研究  

Asymmetric Hydrogenation of Cyclic Dehydroamino Acids and Their Derivatives

作　　者：王英杰[1] 张振锋[2] 张万斌[1,2] 

机构地区：[1]上海交通大学化学化工学院,上海200240 [2]上海交通大学药学院,上海200240

出　　处：《有机化学》2015年第3期528-538,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21202096)资助项目~~

摘　　要：手性环状氨基酸具有独特的结构和特殊的性能,是广泛存在于手性药物和手性催化剂中的一种结构单元.过渡金属催化的不对称氢化具有高效、绿色和经济的优点而成为合成该类化合物的首选方法.对该领域进行了综述,介绍了各种类型环状α-和β-脱氢氨基酸及其衍生物的不对称催化氢化研究现状,分析了各种类型钌(Ru)、铑(Rh)和铱(Ir)催化剂的优势和不足,并提出了该领域今后的研究重点和发展方向.Chiral cyclic amino acids, possessing the unique structure and special properties, can be found in various chiral drugs and chiral catalysts as structural motifs. Transition-metal-catalyzed asymmetric hydrogenation, which has the advantages of high efficiency, environmental friendliness and atom economy, becomes the preferred method for the syntheses of such compounds. The related works on this field are reviewed for the first time in this paper. The catalytic asymmetric hydrogenation of various types of cyclic α- and β-dehydroamino acids and their derivatives is introduced, and the advantages and disadvantages of different kinds of transition-metal catalysts（including complexes of Ru, Rh, and Ir） are discussed. Thus a perspective is proposed for the future development.

关 键 词：环状氨基酸 环状脱氢氨基酸 不对称氢化 钌催化 铑催化 铱催化 

分 类 号：O621.251[理学—有机化学]