1,7-二芳基-1,6-庚二炔化合物的合成  

Synthesis of 1,7-Diarylhepta-1,6-diyne Compounds

作　　者：温燕梅[1] 谢建英[1] 冯润光[1] 黄绪明[1] 

机构地区：[1]广东海洋大学理学院,湛江524088

出　　处：《有机化学》2015年第3期735-738,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21172076)资助项目~~

摘　　要：1,6-庚二炔是有机合成的重要中间体,我们以Pd Cl2/Cu I为催化剂,NEt3为碱,在四氢呋喃溶剂中实现了二炔与卤代芳烃Sonogashira偶联反应,合成了10个1,7-二芳基-1,6-庚二炔化合物,该方法也适用于二卤芳烃如1,8-二碘萘与末端炔偶联合成1,8-二苯乙炔基萘.所有合成的目标化合物结构经1H NMR,13C NMR,IR和MS表征.Hepta-1,6-diynes are very useful synthetic intermediates. Using Pd Cl2/Cu I as the catalyst and NEt3 as the base in tetrahedrofuran, ten 1,7-diarylhepta-1,6-diynes were synthesized by a simple Sonogashira coupling reaction of terminal diacetylenes and aryl halides. It is also indicated that 1,8-diiodonaphthalene can undergo the same transformation to 1,8-bis（phenylethynyl）naphthalene under typical conditions. Moreover, the structures of hepta-1,6-diyne derivatives were confirmed by 1H NMR, 13 C NMR, IR and MS techniques.

关 键 词：钯催化 1 6-庚二炔 SONOGASHIRA反应 

分 类 号：O625.12[理学—有机化学]