血浆纤维蛋白原在阑尾炎患者中的变化及临床意义  

The changes and its clinical significance of plasma fibrinogen in patients with appendicitis

作　　者：肖忠[1] 庄炯宇[1] 蔡家骥[1] 袁春雷[2] 陈伟强[3] 程国何[3] 

机构地区：[1]南方医科大学附属中山博爱医院急诊科,广东中山528403 [2]南方医科大学附属中山博爱医院检验科 [3]南方医科大学附属中山博爱医院外科

出　　处：《临床急诊杂志》2015年第3期167-169,共3页Journal of Clinical Emergency

基　　金：中山市卫生局医学科研立项(No:2013J133)

摘　　要：目的:探讨纤维蛋白原(Fib)在阑尾炎患者中的变化及其临床意义。方法:回顾性分析我院手术、病理证实的阑尾炎患者404例,按其分型分单纯组59例,化脓组263例,坏疽组82例,均采用全自动血凝仪检测Fib含量。结果:化脓组、坏疽组的Fib、WBC均高于单纯组,差异有统计学意义(P<0.01),而坏疽组Fib、WBC又高于化脓组,差异有统计学意义(P<0.01)。Fib与WBC相关性呈正相关(r=0.257,P<0.01)。结论:在阑尾炎时Fib、WBC变化是随病理分型而变化,病情越重Fib、WBC越高,故Fib与WBC一样对判断阑尾炎病情轻重及预分型有一定价值,有望为临床治疗决策提供参考依据。Objective：To explore the changes and its clinical significance of plasma fibrinogen（Fib）in patients with appendicitis.Method：404patients with appendicitis who had been diagnosed by operation and pathological examination in our hospital were chose and divided into 3groups（the simple group,59cases;the purulent group,263cases;the gangrene group,82cases）according to the pathological types.Fib content of 3groups were detected by automatic blood clots instrument.Result：Fib and WBC of patients in the purulent group and the gangrene group were higher than those of the simple group,and there were statistically significances（P〈0.01）.Meanwhile,Fib and WBC of the gangrene group was higher than that of the purulent group with statistically significance（P〈0.01）.Fib was positively correlated with WBC with a correlation coefficient of 0.257（P〈0.01）.Conclusion：The changes of Fib and WBC in patients with appendicitis were related to their pathological types.The more severe the disease,the higher the Fib and WBC.Fib is valuable as WBC in determining the severity of appendicitis and preclassification.

关 键 词：阑尾炎 纤维蛋白原 WBC 凝血功能 血液循环 

分 类 号：R574.61[医药卫生—消化系统]