听觉事件相关电位P300对社区老年人认知功能的评价效果  

Evaluation effect of auditory event related potential P300 on cognitive function of the community elderly people

作　　者：张磊华 何冰 卢国华[3] 

机构地区：[1]解放军第八十九医院人力资源部,潍坊261021 [2]潍坊护理职业学院大外科教研室,262500 [3]潍坊医学院护理学院

出　　处：《中国实用护理杂志》2015年第8期556-558,共3页Chinese Journal of Practical Nursing

基　　金：基金项目：山东省自然科学基金（zR2010HM042、ZR2011HM002）

摘　　要：目的分析社区不同认知功能水平老年人听觉事件相关电位P300的差异，为确定社区老年人的认知水平提供依据。方法2011年10月至2013年10月从潍坊市5个社区筛选阿尔茨海默病（AD）患者32例、轻度认知功能障碍（MCI）患者35例和无明显认知功能障碍的健康老年人35例作为研究对象，分别列为AD组、MCI组和对照组，应用简易精神状态量表（MMSE）测定受试者认知功能状态，同时应用美国Neuroscan公司生产的ESI一64导脑电信号采集记录仪被动听觉oddball范式记录各组事件相关电位P300的情况，评估受试者认知功能状况。结果MCI组P300潜伏期为（378．17±24．62）ms，显著长于对照组的（338．03±43．03）ms，差异有统计学意义，波幅为（12．35±4．02）μv，显著短于对照组的（15．59±5．99）μv，差异有统计学意义。AD组P300潜伏期为（425．43±32．11）ms，显著长于MCI组和对照组；波幅为（8．56±5．21）μv，显著低于对照组和MCI组，差异均有统计学意义。结论社区老年人在听觉事件相关电位P300潜伏期延长及波幅减低的现象有助于对社区老年人认知功能受损程度的判断。在无损害的诊断与评定社区老年人认知功能障碍方面有重要价值。Objective The research aimed to analyze the differences of auditory event related po- tential P300 in elderly people with different levels of cognitive function in order to provide the basis for confirming the cognitive level in community. Methods Thirty- two patients with Alzheimer disease （AD group）, thirty-five MCI patients （MCI group） and thirty-five normal people （normal group） were selected from five communities in Weifang from October 2011 to October 2013. The cognitive level of these subjects was evaluated with Mini Mental State Examination（MMSE） and the event related potential P300 of these pa- tients were recorded with a passive auditory oddball paradigm using the ESI - 64 system（Neumscan Inc.,USA） which was used for collecting and recording EEG signals. Results The latencies of MCI group showed signifi- candy prolonged values [（378.17±24.62） ms, P〈0.01], and lower amphtudes [（12.35±4.02）μV, P〈0.05] of the P300 compared with normal control [ （15.59±5.99）μV, P〈0.05 ]. The latencies of AD group showed signifi- candy prolonged values [（425.43±32.11 ） ms, P〈0.01 ）], and lower amplitudes [（8.56±5.21 ）μV, P〈0.01] of the P300 compared with normal group and MCI group. Conclusions The prolonged latency and lower amplitude of auditory event related potential P300 measurement contribute to diagnose the degree of cogni- tive dysfunction in the elderly. It holds important value for noninvasive diagnosis and evaluation of cognitive dysfunction among the elderly in community.

关 键 词：老年人 阿尔茨海默病 认知障碍 听觉 事件相关电位 P300 社区 

分 类 号：R749.16[医药卫生—神经病学与精神病学]