响应面设计优化地黄中梓醇的提取工艺研究  被引量:7

Optimization of Extracting Total Catalpol from Rehmannia glutinosa Libosch. by Response Surface Design

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作  者:张路[1] 王春艳[1] 李士栋[1] 李民[1] 赵婷婷[1] 张淹[1] 

机构地区:[1]山东东阿阿胶股份有限公司,国家胶类中药工程技术研究中心,山东聊城252201

出  处:《中国药物评价》2015年第1期12-16,共5页Chinese Journal of Drug Evaluation

摘  要:目的:研究优化地黄中梓醇的提取工艺。方法:在单因素分析的基础上,以梓醇含量为响应值,采用响应面设计法对其提取工艺进行研究。结果:最佳工艺条件为乙醇浓度80%,提取温度85℃,料液比为1∶8,提取时间为60 min。结论:优选工艺稳定可靠,可为工业生产提供参考依据。Objective: To exa mine the procedure for the chemical extraction of the catalpol in Rehmannia glutinosa Libosch.Methods: The procedure for the extraction was performed with the content of Catalpol as the response. Response surface design was applied to find the optimum parameters which is based on one-factor experiment. Results: The best experimental conditions were found to be extraction at 85 ℃ for 60 min using the amount of 80% ethanol solvent with an S / L ratio of 1∶ 8. Conclusion: Optimized extraction technology was stable and reliable,could provide reference for industrial production.

关 键 词:响应面设计 地黄 梓醇 

分 类 号:R284.2[医药卫生—中药学]

 

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