Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees  

作　　者：Babs E Verstrepen André Boonstra Gerrit Koopman 

机构地区：[1]Department of Virology,Biomedical Primate Research Centre,2280GH Rijswijk,The Netherlands [2]Department of Gastroenterology and Hepatology,Erasmus University Medical Center Rotterdam,3015 CE Rotterdam,The Netherlands

出　　处：《World Journal of Hepatology》2015年第1期53-69,共17页世界肝病学杂志（英文版）（电子版）

基　　金：Supported by In part the Fifth framework program from the EU,No.BIO-CT98-0357,QLK2-CT-1999-00356 and ERC2008-Ad G-233130-HEPCENT(Verstrepen BE);by the Virgo consortium,funded by the Dutch government project,No.FES0908(Boonstra A)

摘　　要：Hepatitis C virus(HCV) infection is characterized by a high propensity for development of life-long viral persistence. An estimated 170 million people suffer from chronic hepatitis caused by HCV. Currently,there is no approved prophylactic HCV vaccine available.With the near disappearance of the most relevant animal model for HCV,the chimpanzee,we review the progression that has been made regarding prophylactic vaccine development against HCV. We describe the results of the individual vaccine evaluation experiments in chimpanzees,in relation to what has been observed in humans. The results of the different studies indicate that partial protection against infection can be achieved,but a clear correlate of protection has thus far not yet been defined.Hepatitis C virus （HCV） infection is characterized bya high propensity for development of life-long viralpersistence. An estimated 170 million people sufferfrom chronic hepatitis caused by HCV. Currently, thereis no approved prophylactic HCV vaccine available.With the near disappearance of the most relevantanimal model for HCV, the chimpanzee, we review theprogression that has been made regarding prophylacticvaccine development against HCV. We describe theresults of the individual vaccine evaluation experimentsin chimpanzees, in relation to what has been observedin humans. The results of the different studies indicatethat partial protection against infection can be achieved,but a clear correlate of protection has thus far not yetbeen defined.

关 键 词：Hepatitis C virus Vaccines CHIMPANZEES Review PROPHYLACTIC ANTIBODIES T-CELLS 

分 类 号：R512.63[医药卫生—内科学]