消栓通络有效成分组对脑缺血再灌注大鼠的神经保护作用  

Protective effects of effective components group of Xiaoshuantongluo on cerebral ischemia/reperfusion injury in rats

作　　者：庞晓斌[1] 王琳[1] 赵艳[2] 陈若芸[3] 谢欣梅[1] 杜冠华[3] 

机构地区：[1]河南大学药物研究所,河南开封475004 [2]青岛市市立医院,山东青岛266011 [3]中国医学科学院&北京协和医学院药物研究所国家药物筛选中心,北京100050

出　　处：《河南大学学报（医学版）》2015年第1期10-12,20,共4页Journal of Henan University:Medical Science

基　　金：国家自然科学基金资助项目(81273652)

摘　　要：目的探讨消栓通络有效成分组(XECG)对脑缺血/再灌注大鼠的神经保护作用。方法采用线栓法阻断大脑中动脉(MCAO)建立大鼠脑缺血/再灌注(I/R)模型。缺血2h,再灌注24h时后,通过腹腔给予XECG(200、100、50mg·kg-1),以脑梗死体积、脑含水量和伊文思蓝(Evans Blue,EB)法检测血脑屏障通透性等指标评价XECG对脑缺血的神经保护作用。结果 XECG能显著降低缺血再灌注大鼠脑梗塞体积和血脑屏障通透性。结论 XECG对脑缺血损伤有直接的神经保护作用。Objective To investigate the protective effect of effective components group of Xiaoshuantongluo（XECG）on ischemia/reperfusion（I/R）injury in rats.Methods Middle cerebral artery occlusion was adopted to establish the rat ischemia/reperfusion model.Healthy male adult Sprague Dawley rats were randomly divided into the sham operation group,the model group,the nimodipine（4mg·kg-1）group,and high,middle and low dose XECG groups（200,100,50mg·kg-1）.Cerebral infarction volume and blood brain barrier permeability were respectively detected by TTC method and Evans Blue（EB）leakage.Results Compared with the I/R model group,XECG could significantly reduce the cerebral infarction volume and remarkably decreased blood brain barrier permeability.Conclusion XECG has obviously protective effect on Sprague Dawley rats after cerebral ischemia and reperfusion.

关 键 词：XECG 脑缺血 梗死体积 血脑屏障 

分 类 号：R743.3[医药卫生—神经病学与精神病学]