奥曲肽联合奥美拉唑治疗食管胃底静脉曲张破裂出血疗效观察  

The curative effect observation of combined octreotide and omeprazole for the treatment of esophageal variceal bleeding

作　　者：伍小青[1] 

机构地区：[1]江山市人民医院消化内科,浙江省江山324100

出　　处：《中国基层医药》2015年第5期717-719,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨奥曲肽联合奥美拉唑治疗食管胃底静脉曲张破裂出血（ BEV ）的临床效果，并观察、分析其安全性，为临床提供客观依据。方法选择92例BEV患者，根据治疗方法分为对照组和观察组，对照组45例，应用奥曲肽治疗；观察组47例，在对照组基础上联合奥美拉唑治疗。观察两组治疗效果、48 h再出血率、止血时间、输血量以及不良反应。结果观察组总有效率为93．62％，高于对照组的82．22％，差异有统计学意义（χ2＝6．24，P＜0．05）；观察组无效率为6．38％，低于对照组的17．78％，差异有统计学意义（χ2＝6．17，P＜0．05）；观察组止血时间（30．41±1．82）h，短于对照组的（41．83±2．69）h，差异有统计学意义（t＝9．47，P＜0．05）；观察组输血量为（374．16±28．30） mL，少于对照组的（582．33±36．19） mL，差异有统计学意义（t＝12．31，P＜0．05）；观察组48 h再出血率为6．38％，低于对照组的20．00％，差异有统计学意义（χ2＝5．90，P＜0．05）；两组不良反应差异无统计学意义（χ2＝2．78，P＞0．05）。结论奥曲肽联合奥美拉唑治疗BEV能够显著提高治疗效果，降低再出血率，缩短止血时间，减少输血量，且无明显不良反应。Objective To explore the clinical effect of combined octreotide and omeprazole for the treatment of bleeding of esophageal and gastric varices（BEV）,analyze its security and provide objective basis for clinical treatment. 〈br〉 Methods 92 patients with BEV were randomly selected .According to the treatment methods , they were randomly divided into the control group and observation group .45 cases in the control group were treated with octreotide ,47 cases in observation group were treated with omeprazole on the basis of the control group .The main indexes were the treatment effect,48h rebleeding rate,bleeding time and volume of blood transfusion and adverse reaction .Results The total effective rate of the observation group was 93.62%,more than that of control group 82.22%,the difference was statistically significant（χ2 =6.24,P〈0.05）.The effective rate of the observation group was 6.38%,lower than that of the control group 17.78%,the difference was statistically significant （χ2 =6.17,P〈0.05）.The bleeding time of the observation group was （30.41 ±1.82） h,less than that of the control group （41.83 ±2.69） h,the difference was statistically significant （t =9.47,P〈0.05）.The blood transfusion of the observation group was （374.16 ± 28.30）mL,less than the control group（582.33 ±36.19）mL,the difference was statistically significant （t=12.31, P〈0.05）.48h the rebleeding rate of the observation group was 6.38%,lower than that of the control group 20.00%,the difference was statistically significant （χ2 =5.90,P〈0.05）.The adverse reactions of two groups had no significant difference（χ2 =2.78,P＆gt;0.05）.Conclusion There is the better for clinical effect of combined octreoti-de and omeprazole for the treatment of BEV , which could reduce the rebleeding rate , shorten the bleeding time , decrease the volume of blood transfusion ,and there was no obvious adverse reactions .

关 键 词：食管和胃静脉曲张 奥曲肽 奥美拉唑 

分 类 号：R575.2[医药卫生—消化系统]