基因重组人骨形成蛋白-2和牛骨形成蛋白异位诱导成骨的比较  

Bone formation induced by purified BMP and by recombinant human BMP-2

作　　者：戴毅敏[1] 陈新梅[2] 毛天球[1] 韩亮[1] 马秦[1] 陈富林[1] 

机构地区：[1]西安第四军医大学口腔医学院,710032 [2]成都四川大学口腔医学院

出　　处：《实用口腔医学杂志》2002年第4期326-328,共3页Journal of Practical Stomatology

摘　　要：目的 :观察基因重组人骨形成蛋白 2 (rhBMP 2 )和牛骨形成蛋白 (bBMP)分别与珊瑚 /聚乳酸形成复合人工骨的异位诱导成骨活性 ,同时比较两种骨形成蛋白的成骨效率。方法 :把rhBMP 2和bBMP分别与珊瑚 /聚乳酸形成复合人工骨 ,进行小鼠肌内种植 1、3、6周后 ,组织学观察和组织形态测量 ,比较其异位诱导成骨活性。结果 :rhBMP 2和bBMP存在骨诱导差异 ,rhBMP 2诱导成骨量相对较少但血管、骨髓含量丰富 ,bBMP则相反。结论 :两种BMP都具有良好的诱骨活性 ,但在成骨量和血管。Objective: To study the biodegradable of coral PLA composite artifical bone combined with bBMP or rhBMP as a new kind of bone substitute material. Methods: The composites were implanted into the muscle pouches of mice after combined with rhBMP-2 or bBMP respectively. Ectopic osteoinductive activity of rhBMP-2 or bBMP was examined and compared by histology and histo-morphometry.Results: rhBMP-2 and bBMP had different osteoinductivety. rhBMP-2 appeared to induce less bone and more angioid tissue and marrow. While bBMP seemed to have opposite effects. Conclusion: bBMP is more osteoinductive than rhBMP-2.

关 键 词：基因重组 人骨形成蛋白-2 牛骨形成蛋白 异位诱导 成骨活性 实验研究 

分 类 号：R780.2[医药卫生—口腔医学]