姜黄素与双胍衍生物的合成及性质研究  

Preparation and Properties of the Curcumin and Biguanides Derivatives

作　　者：杨慧鑫 刘巨涛[1] 张翠云[1,2] 刘文桐 徐启超[1] 

机构地区：[1]大连民族学院生命科学学院,辽宁大连116600 [2]辽宁师范大学化学化工学院,辽宁大连116029

出　　处：《广东化工》2015年第5期23-24,13,共3页Guangdong Chemical Industry

基　　金：国家自然科学基金资助项目(No.20872013)

摘　　要：分别以三种芳胺和三种杂环胺合成六种盐酸盐,再与双氰胺反应合成六种双胍类盐酸盐,最后将姜黄素与六种双胍类衍生物进行反应,最终合成六种姜黄素双胍类衍生物。通过IR、1H NMR、13C NMR对其结构进行了表征,初步证明合成了目标产物;利用循环伏安方法对目标产物进行了电化学性质研究,考察了在酸性条件下不同扫描速率下目标产物氧化还原峰位置的变化,表明反应过程受电极/溶液界面间的吸附控制。对目标产物进行了金黄色葡糖糖球菌的抑菌活性的研究,结果表明目标产物均有很好的抑菌效果。Curcumin and biguanides derivatives were synthesized with three kinds of aromatic amines,three kinds of heterocyclic amines,dicyandiamide and curcumin,using the organic synthesis method.The six kinds of curcumin and biguanides derivatives were confirmed by IR,1H NMR and 13 C NMR.The CV was used to investigate the electrochemical property of the six kinds of curcumin and biguanides derivatives.The results showed that the reaction process was affected by adsorption control through different scan rate in the electrode/solution interface under acidic condition.The six kinds of curcumin and biguanides derivatives were explored with Staphylococcus aureus,the results showed that the inhibition effect of the curcumin and biguanides derivatives were well.

关 键 词：姜黄素 循环伏安法 双胍 抑菌活性 

分 类 号：TQ[化学工程]