阿戈美拉汀的晶型制备表征及性质研究——药物多晶型综合设计性实验  

Study on crystal preparation,characterization and property of Agomelatine:A comprehensive design experiment related to drug crystallization

作　　者：郑赛利[1] 许先芳[1] 李莲云[1] 朱可佳[1] 

机构地区：[1]中山大学化学与化学工程学院,广东广州510275

出　　处：《实验技术与管理》2015年第2期58-60,共3页Experimental Technology and Management

基　　金：中山大学实验教学研究(改革)基金项目(YJ201317)

摘　　要：应用溶剂挥发、加入反溶剂、熔融等方法对固体药物阿戈美拉汀进行重结晶,能够得到3种晶型,分别使用红外光谱测定、差示扫描量热分析(DSC)、质谱(MS)等仪器分析方法进行表征,比较了所得晶型的稳定性以及溶解度等性质。该实验结合了化学与生物学热点问题,综合性较强,可作为大学本科综合实验的教学内容。In this study,three crystal forms of solid drug Agomelatine were prepared by the methods of solvent evaporation,adding reverse solvent and melting.They were characterized by infrared spectrum,DSC analyses and ESI-MS.Moreover,their distinct melting points and solubilities were investigated.This experiment integrating chemical and biological hot issue is suitable to be designed as a comprehensive chemical experiment.

关 键 词：综合化学实验 晶型制备 仪器表征 性质比较 

分 类 号：R914.1[医药卫生—药物化学]