丙戊酸和托吡酯治疗癫癎患者长程视频脑电图分析比较  

COMPARISON OF LONG-TERM VIDEO-EEG OF PATIENTS WITH EPILEPSY AFTER TREATING WITH TOPIRAMATE AND VALPROATE

作　　者：刁芳明[1] 徐鋆阳[1] 李秋玲[1] 莫志铭[1] 石红婷[1] 陈霄莲[1] 徐凤霞[1] 董亚贤[2] 胡湘蜀 钟高贤[4] 

机构地区：[1]广州医科大学附属第四医院神经内科,511447 [2]广州医科大学附属第一医院神经内科 [3]广东三九脑科医院癫癎诊疗中心 [4]广州医科大学附属第二医院神经内科

出　　处：《现代电生理学杂志》2015年第1期3-6,18,共5页Journal of Modern Electrophysiology

摘　　要：目的:分析比较口服丙戊酸(Valproate,VPA)和托吡酯(Topiramate,TPM)对癫癎患者长程视频脑电图的影响。方法:对152例单独应用丙戊酸和129例单独应用托吡酯至少两年无发作的癫癎患者脑电图进行分析和比较,所有患者进行至少2次24小时长程视频脑电图检查,期间间隔至少2年。结果:结果:丙戊酸钠组,136例患者癫癎发作波明显减少或消失,15例患者癫癎发作波无明显减少,1例患者癫癎发作波增加;托吡酯组,112例患者癫癎发作波明显减少或消失,16例患者癫癎发作波无明显减少,1例患者癫癎发作波增加。两组比较,差异无统计学意义。结论 :丙戊酸钠和托吡酯均可使症状性癫癎或原发性癫癎的临床发作得到控制,与脑电图的改变基本一致。Objective： To compare influence of long-term video EEG of patients with epilepsy after treating with topiramate and valproate. Methods： 152 patients with epilepsy treating with valproate lonely and 129 patients with epilepsy treating with topiramate lonely were analyzed, all the patients were seizure-free for at least two years. All the patients had video-electroencephalogram examination for at least two times. Results： In the valproate group, the epilepsy wave of 136 patients disappeared or significantly reduced, 15 patients changed nothing, and 1 patient increased. In the topiramate group, the epilepsy wave of 112 patients disappeared or significantly reduced, 16 patients changed nothing, and 1 patient increased. Conclusion： Both topiramate and valproate can control the symptom of idiopathic epilepsy and symptomatic epilepsy, at the same time the epilepsy wave of most patients significantly reduced or disappeared.

关 键 词：托吡酯 丙戊酸 癫癎 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学]