重组人生长激素联合支链氨基酸对肝硬化患者肿瘤坏死因子-α和白细胞介素-10的影响  

Effect of recombinant human growth hormone combined with branched chain amino acid on the levels of tumor necrosis factor-α and interleukins-10 in patients with hepatic cirrhosis

作　　者：马铭[1] 袁耀宗[2] 刘建生[1] 田怡[1] 张晓红[1] 刘海玲[1] 

机构地区：[1]上海瑞金医院集团闵行区中心医院消化内科,201199 [2]上海瑞金医院消化内科,200025

出　　处：《蚌埠医学院学报》2015年第3期357-358,361,共3页Journal of Bengbu Medical College

基　　金：上海市闵行区自然科学研究基金资助项目(2007MH045)

摘　　要：目的：探讨重组人生长激素（r-h GH）联合应用支链氨基酸（BCAA）对肝硬化失代偿期患者肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）的影响。方法：将82例肝硬化失代偿期患者随机分为治疗组42例和对照组40例。在相同保肝、支持治疗基础上,治疗组应用r-h GH 5 IU,每2天1次皮下注射,同时联用BCAA 250 ml,每天1次静脉滴注,连用20 d。对照组应用BCAA 250 ml,静脉滴注,每天1次,连用20 d。观察治疗前和治疗结束后第2天患者肝功能和TNF-α、IL-10水平变化情况。结果：2种治疗方法对患者肝功能指标、血清TNF-α和IL-10水平均有改善,但治疗组在纳差、下肢水肿等症状改善及丙氨酸氨基转移酶、白蛋白和血清TNF-α、IL-10水平改善方面均优于对照组（P〈0.05~P〈0.01）。结论：r-h GH联合BCAA在改善患者血清白蛋白和改善TNF-α、IL-10水平等方面优于单纯应用BCAA。Objective： To investigate the effects of recombinant human growth hormone（ r-h GH） combined with branched chain amino acid（ BCAA） on the levels of Tumor necrosis factor-α（ TNF-α） and interleukins-10（ IL-10） in patients with decompensated cirrhosis.Methods： Eighty-two patients with decompensated cirrhosis were randomly divided into the treatment group（ 42 cases） and control group（ 40 cases）. The treatment group and control group were treated with 5 IU of r-h GH by subcutaneous injection 1 time two days combined with 250 ml of BCAA by intravenous drip once a day for 20 d and 250 ml of BCAA by intravenous drip once a day for 20 d based on protecting liver and support treatment,respectively. The liver function and levels of TNF-α and IL-10 in two groups were observed before and after treatment. Results： The liver function and levels of TNF-α and IL-10 in two groups were improved,the improvement of poor appetite,lower limbs edema,and the levels of alanine aminotransferase,albumin,TNF-α and IL-10 in treatment group were better than those in control group（ P 〈0. 05 to P〈 0. 01）. Conclusions： The effects of r-h GH combined with BCAA on the improvement of serum albumin,TNF-α and IL-10 levels are better than those of BCAA alone.

关 键 词：肝硬化 重组人生长激素 支链氨基酸 肿瘤坏死因子-Α 白细胞介素-10 

分 类 号：R575.2[医药卫生—消化系统]