CRLF2基因在儿童B系急性淋巴细胞性白血病中的研究进展  

A review on the gene of CRLF2 in childhood B-cell precursor acute lymphocytic leukemia

作　　者：姜敏[1] 胡东[1] 金润铭 

机构地区：[1]华中科技大学同济医学院附属协和医院儿科,武汉430022 [2]厦门市第五医院儿科,361101

出　　处：《国际儿科学杂志》2015年第2期163-166,共4页International Journal of Pediatrics

摘　　要：儿童急性淋巴细胞性白血病的危险分层可用以指导治疗和评估预后.但临床特征提示预后良好以及早期治疗反应良好的患者仍占复发和死亡患者很大一部分比例.因此,研究与复发相关的基因异常将有利于提高患儿的治愈率.CRLF2基因的异常表达与JAK变异、BCR/ABL1样信号、IKZF缺失相关,其高表达与儿童B系急性淋巴细胞性白血病高危复发及不良预后相关,但其预后价值尚有争议.该文阐述CRLF2基因在儿童B系急性淋巴细胞性白血病中的研究进展.Current risk classification in childhood B-cell precursor acute lymphocytic leukemia has been used to modulate the intensity of treatment and prognosis assessment.However there are a significant proportion of relapses and deaths occur among childhood with good risk clinical characteristics and/or an excellent early response to therapy.So research about the aberrant expression of gene associated with relapse will improve cure rate.Aberrant expression of CRLF2 gene can be found in childhood B-cell precursor acute lymphocytic leukemia and associated with JAK aberrantion,BCR-ABL1-like signature,IKZF deletion.Over-expression of CRLF2 gene is associated with high risk relapse and poor outcome in childhood B-cell precursor acute lymphocytic leukemia,but its prognostic value is still controversial.This article mainly reviews the progress of CRLF2 gene in childhood B-cell precursor acute lymphocytic leukemia.

关 键 词：细胞因子受体样因子2基因 急性淋巴细胞性白血病 儿童 

分 类 号：R733.71[医药卫生—肿瘤]